NAT2 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		NAT2	PALB2
Description		N-acetyltransferase 2	partner and localizer of BRCA2
Image
GO Annotations	Cellular Component	Cytosol	Nucleoplasm
	Molecular Function	Arylamine N-acetyltransferase Activity Protein Binding	DNA Binding Protein Binding
	Biological Process	Xenobiotic Metabolic Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		Acetylation	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases			Fanconi anemia
GWAS		Bladder cancer ( 24163127 20972438) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Cholesterol, total ( 24097068 20686565) Coronary artery disease ( 29212778) Insulin resistance/response ( 25798622) Iron status biomarkers (transferrin levels) ( 25352340) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver injury in anti-tuberculosis drug treatment ( 31109976) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Paclitaxel-induced neuropathy ( 23776197) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 20686565) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407 21572414) Urinary metabolites (H-NMR features) ( 24586186)	Bipolar disorder ( 17554300)
Interacting Genes		16 interacting genes: APC APP AURKA BAG4 CDKN2A CDKN2C ERBB2 FZR1 HMMR IGF1R NAA10 NBN PALB2 PPM1D STK11 WT1	28 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		10	79728
HPRD ID		02000	07966
Ensembl ID		ENSG00000156006	ENSG00000083093
Uniprot IDs		A4Z6T7 P11245	H3BN63 Q86YC2
PDB IDs		2PFR	2W18 3EU7
Enriched GO Terms of Interacting Partners?
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