PKHD1

Description		PKHD1 ciliary IPT domain containing fibrocystin/polyductin
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Cell Cytoplasm Centrosome Cilium Integral Component Of Membrane Apical Plasma Membrane Anchored Component Of External Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	Kidney Development Cellular Calcium Ion Homeostasis Positive Regulation Of Cell Proliferation Regulation Of Centrosome Duplication Regulation Of TOR Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Homeostatic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cellular Component Movement Negative Regulation Of Protein Kinase B Signaling Cilium Assembly Regulation Of ERK1 And ERK2 Cascade Cell-cell Adhesion
Pathways
Drugs
Diseases		Polycystic kidney disease
GWAS		Alcohol use disorder ( 30940813) Chronotype ( 30696823) Coffee consumption ( 31046077) Diastolic blood pressure ( 28135244 27841878) Epigenetic age acceleration in alcohol use disorder ( 31466081) Estimated glomerular filtration rate ( 31152163) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998 24002674 29785010 31959993 30054594 29235454) Longevity ( 30294719) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 17903305) Red vs. brown/black hair color ( 30531825) Response to fenofibrate (triglyceride levels) ( 27002377) Tea consumption ( 31046077) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197) Weight loss (gastric bypass surgery) ( 23633212)
Interacting Genes		1 interacting genes: CAMLG
Entrez ID		5314
HPRD ID		05987
Ensembl ID		ENSG00000170927
Uniprot IDs		P08F94
PDB IDs
Enriched GO Terms of Interacting Partners?
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