| Novel |
ANAPC5
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anaphase promoting complex subunit 5 |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- Assembly of the pre-replicative complex
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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| Novel |
ARL6IP4
|
ARF like GTPase 6 interacting protein 4 |
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| Novel |
DIABLO
|
diablo IAP-binding mitochondrial protein |
- Release of apoptotic factors from the mitochondria
- SMAC (DIABLO) binds to IAPs
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC, XIAP-regulated apoptotic response
- Regulation of the apoptosome activity
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| Novel |
TRIAP1
|
TP53 regulated inhibitor of apoptosis 1 |
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- Mitochondrial protein degradation
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| Novel |
ZCCHC8
|
zinc finger CCHC-type containing 8 |
- Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
- Nuclear RNA decay
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DSCR9
|
Down syndrome critical region 9 |
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GSK3A
|
glycogen synthase kinase 3 alpha |
- AKT phosphorylates targets in the cytosol
- XBP1(S) activates chaperone genes
- Constitutive Signaling by AKT1 E17K in Cancer
- Suppression of apoptosis
- Maturation of nucleoprotein
- Maturation of nucleoprotein
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