RHOA - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ACKR2	atypical chemokine receptor 2	Chemokine receptors bind chemokines
Novel	AMT	aminomethyltransferase	Glycine degradation	Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid	Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
Novel	ARF4	ARF GTPase 4	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Guanosine-5'-Diphosphate
Novel	ARIH2	ariadne RBR E3 ubiquitin protein ligase 2	Antigen processing: Ubiquitination & Proteasome degradation
Novel	C1QA	complement C1q A chain	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
Novel	CAMP	cathelicidin antimicrobial peptide	Neutrophil degranulation Antimicrobial peptides	Selenocysteine
Novel	ENTPD3	ectonucleoside triphosphate diphosphohydrolase 3	Phosphate bond hydrolysis by NTPDase proteins
Novel	GPX1	glutathione peroxidase 1	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species	Glutathione Glutathione Glutathione disulfide Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols	Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
Novel	ITIH3	inter-alpha-trypsin inhibitor heavy chain 3	Platelet degranulation	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Novel	KLRG1	killer cell lectin like receptor G1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Novel	PDCD10	programmed cell death 10			Cerebral cavernous malformation
Novel	SUB1	SUB1 regulator of transcription
	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Netrin-1 signaling
	AKAP13	A-kinase anchoring protein 13	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
	ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle
	ARHGAP1	Rho GTPase activating protein 1	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND2 GTPase cycle
	ARHGAP10	Rho GTPase activating protein 10	Regulation of PAK-2p34 activity by PS-GAP/RHG10 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
	ARHGAP11A	Rho GTPase activating protein 11A	RHOA GTPase cycle

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