IRF4 - Wiki-Pi

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28 interactions involving IRF4 - interferon regulatory factor 4 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases

Novel	Symbol	Description	Pathways Hide	Drugs Hide	Diseases Hide
Novel	CUTA	cutA divalent cation tolerance homolog
Novel	FLRT3	fibronectin leucine rich transmembrane protein 3	Signaling by ROBO receptors Downstream signaling of activated FGFR1
Novel	HPSE	heparanase	HS-GAG degradation Neutrophil degranulation
Novel	INSL4	insulin like 4
Novel	NEDD9	neural precursor cell expressed, developmentally down-regulated 9
Novel	TBCC	tubulin folding cofactor C	Post-chaperonin tubulin folding pathway
	BATF	basic leucine zipper ATF-like transcription factor	Interleukin-4 and Interleukin-13 signaling
	BCL6	BCL6 transcription repressor	Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes		Hairy-cell leukemia
	ELP1	elongator acetyltransferase complex subunit 1	HATs acetylate histones
	ETV7	ETS variant transcription factor 7
	FKBP4	FKBP prolyl isomerase 4	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
	GIPC2	GIPC PDZ domain containing family member 2
	HOXB13	homeobox B13
	HOXC11	homeobox C11	Formation of the ureteric bud
	IRAK1	interleukin 1 receptor associated kinase 1	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	Fostamatinib
	MYD88	MYD88 innate immune signal transduction adaptor	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
	NFATC2	nuclear factor of activated T cells 2	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
	PRDM1	PR/SET domain 1	Regulation of TP53 Expression STAT3 nuclear events downstream of ALK signaling Specification of primordial germ cells
	PROX1	prospero homeobox 1
	SPI1	Spi-1 proto-oncogene	RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis		Acute myeloid leukemia (AML)

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