| Novel |
PGAP3
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post-GPI attachment to proteins phospholipase 3 |
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| Novel |
PPP1R1B
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protein phosphatase 1 regulatory inhibitor subunit 1B |
- DARPP-32 events
- DARPP-32 events
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| Novel |
TBC1D3F
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TBC1 domain family member 3F |
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BAX
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BCL2 associated X, apoptosis regulator |
- Release of apoptotic factors from the mitochondria
- Activation, translocation and oligomerization of BAX
- Pyroptosis
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- Transcriptional regulation by RUNX2
- NTRK3 as a dependence receptor
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BBC3
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BCL2 binding component 3 |
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Activation of PUMA and translocation to mitochondria
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- FOXO-mediated transcription of cell death genes
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PIK3C3
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phosphatidylinositol 3-kinase catalytic subunit type 3 |
- PI3K Cascade
- Macroautophagy
- Synthesis of PIPs at the Golgi membrane
- Synthesis of PIPs at the early endosome membrane
- Synthesis of PIPs at the late endosome membrane
- Toll Like Receptor 9 (TLR9) Cascade
- RHO GTPases Activate NADPH Oxidases
- Translation of Replicase and Assembly of the Replication Transcription Complex
- Translation of Replicase and Assembly of the Replication Transcription Complex
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
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- N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide
- GSK-1059615
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SKP1
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S-phase kinase associated protein 1 |
- Activation of NF-kappaB in B cells
- Prolactin receptor signaling
- SCF-beta-TrCP mediated degradation of Emi1
- Vpu mediated degradation of CD4
- SCF(Skp2)-mediated degradation of p27/p21
- Degradation of beta-catenin by the destruction complex
- Downstream TCR signaling
- NOTCH1 Intracellular Domain Regulates Transcription
- Regulation of PLK1 Activity at G2/M Transition
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
- FCERI mediated NF-kB activation
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- NIK-->noncanonical NF-kB signaling
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- Regulation of RUNX2 expression and activity
- Neddylation
- Interleukin-1 signaling
- Iron uptake and transport
- Negative regulation of NOTCH4 signaling
- Regulation of BACH1 activity
- Nuclear events stimulated by ALK signaling in cancer
- GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
- Antigen processing: Ubiquitination & Proteasome degradation
- GSK3B-mediated proteasomal degradation of PD-L1(CD274)
- Degradation of CRY and PER proteins
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- 1-naphthaleneacetic acid
- (2S)-2-(1H-indol-3-yl)hexanoic acid
- (2S)-2-(1H-indol-3-yl)pentanoic acid
- (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
- Indoleacetic acid
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UBE2D1
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ubiquitin conjugating enzyme E2 D1 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Inactivation of APC/C via direct inhibition of the APC/C complex
- TICAM1, RIP1-mediated IKK complex recruitment
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Signaling by BMP
- Downstream TCR signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated NF-kB activation
- Regulation of TNFR1 signaling
- CLEC7A (Dectin-1) signaling
- Ovarian tumor domain proteases
- Assembly of the pre-replicative complex
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Neddylation
- Peroxisomal protein import
- Negative regulators of DDX58/IFIH1 signaling
- IKK complex recruitment mediated by RIP1
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Inactivation of CSF3 (G-CSF) signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Degradation of CRY and PER proteins
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
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