DYNC1LI2 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	CTRL	chymotrypsin like	Developmental Lineage of Pancreatic Acinar Cells
Novel	FCSK	fucose kinase	GDP-fucose biosynthesis
Novel	HPR	haptoglobin-related protein	Scavenging of heme from plasma	Zinc Copper Zinc acetate
Novel	ZFHX3	zinc finger homeobox 3	RUNX3 regulates CDKN1A transcription
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Gantenerumab Aducanumab Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form Lecanemab	Alzheimer's disease (AD)
	BRCA2	BRCA2 DNA repair associated	HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Impaired BRCA2 binding to SEM1 (DSS1)		Ovarian cancer Fanconi anemia Breast cancer Pancreatic cancer
	DMTN	dematin actin binding protein	Miscellaneous transport and binding events
	GAA	alpha glucosidase	Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Acarbose Miglitol AT2220 alpha-Arbutin	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
	LINC00632	long intergenic non-protein coding RNA 632
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes

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