CSNK2B - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	CIP2A	cellular inhibitor of PP2A
Novel	CRISP2	cysteine rich secretory protein 2
Novel	GTPBP2	GTP binding protein 2	Platelet degranulation
Novel	KCNA3	potassium voltage-gated channel subfamily A member 3	Voltage gated Potassium channels	Enflurane Clofazimine Promethazine Miconazole Dalfampridine
Novel	TRIM27	tripartite motif containing 27	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
Novel	ZFP36L1	ZFP36 ring finger protein like 1	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Novel	ZNF76	zinc finger protein 76
	ABHD4	abhydrolase domain containing 4, N-acyl phospholipase B	Acyl chain remodelling of PE
	ACTB	actin beta	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Quercetin Phenethyl Isothiocyanate	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
	ACTL6B	actin like 6B	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
	ACTR1B	actin related protein 1B	MHC class II antigen presentation Neutrophil degranulation
	ACTR5	actin related protein 5	UCH proteinases DNA Damage Recognition in GG-NER
	ACVRL1	activin A receptor like type 1	Signaling by BMP	ATP	Hereditary hemorrhagic telangiectasia (HHT)
	ADD1	adducin 1	Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events
	ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	Ethanol oxidation	NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
	ANGPT2	angiopoietin 2	Tie2 Signaling	Vanucizumab Faricimab
	ANKRD28	ankyrin repeat domain 28	Telomere Extension By Telomerase COPII-mediated vesicle transport
	AP2M1	adaptor related protein complex 2 subunit mu 1	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
	APLP1	amyloid beta precursor like protein 1		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
	ARAF	A-Raf proto-oncogene, serine/threonine kinase	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	ATP	Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)

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