Search Results for: CDK2

161 interactions involving CDK2 - cyclin dependent kinase 2 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Symbol Description Pathways Hide Drugs Hide Diseases Hide
Novel AOC2 amine oxidase copper containing 2
  • Phase I - Functionalization of compounds
Novel AQP6 aquaporin 6
  • Passive transport by Aquaporins
Novel ARF3 ARF GTPase 3
  • Synthesis of PIPs at the Golgi membrane
  • COPI-mediated anterograde transport
  • COPI-dependent Golgi-to-ER retrograde traffic
Novel CACNB3 calcium voltage-gated channel auxiliary subunit beta 3
  • Presynaptic depolarization and calcium channel opening
  • Adrenaline,noradrenaline inhibits insulin secretion
  • NCAM1 interactions
  • Regulation of insulin secretion
  • Regulation of insulin secretion
  • Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
  • Ergocalciferol
  • Enflurane
  • Ranolazine
  • Phenytoin
  • Topiramate
  • Nimodipine
  • Spironolactone
  • Nicardipine
  • Magnesium sulfate
  • Verapamil
  • Levomenthol
  • Nitrendipine
  • Miconazole
  • Amiodarone
  • Mibefradil
  • Dronedarone
  • Nilvadipine
  • Drotaverine
  • Trimebutine
  • Benidipine
  • Cilnidipine
  • Efonidipine
  • Efonidipine
  • Lacidipine
  • Manidipine
  • Butamben
  • Bioallethrin
  • Bioallethrin
  • Fish oil
Novel CELA1 chymotrypsin like elastase 1
  • N,N-dimethylformamide
  • Cumidine
  • Mdl 101,146
  • 2-[5-Methanesulfonylamino-2-(4-Aminophenyl)-6-Oxo-1,6-Dihydro-1-Pyrimidinyl]-N-(3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl)Acetamide
  • N-{4-[(Carboxymethyl)carbamoyl]benzoyl}-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-3-pentanyl]-L-prolinamide
  • N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-alanyl-L-alaninamide
  • N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide
  • Freselestat
  • (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid
  • (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE
  • (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE
  • [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER
  • METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATE
  • (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID
  • 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE
  • (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID
  • (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID
Novel CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
Novel CSF3 colony stimulating factor 3
  • Other interleukin signaling
  • Interleukin-10 signaling
  • Signaling by CSF3 (G-CSF)
  • Signaling by CSF3 (G-CSF)
  • Inactivation of CSF3 (G-CSF) signaling
  • Inactivation of CSF3 (G-CSF) signaling
Novel ERBB3 erb-b2 receptor tyrosine kinase 3
  • Tucatinib
  • Type I diabetes mellitus
  • Lethal congenital contractural syndrome (LCCS)
Novel GNAO1 G protein subunit alpha o1
  • Ca2+ pathway
  • Ca2+ pathway
Novel MOB1A MOB kinase activator 1A
  • Signaling by Hippo
Novel MS4A3 membrane spanning 4-domains A3
  • Neutrophil degranulation
Novel PAX2 paired box 2
  • Formation of intermediate mesoderm
  • Formation of the nephric duct
  • Formation of the ureteric bud
  • Renal coloboma syndrome (RCS); Papillorenal syndrome
Novel PTPN18 protein tyrosine phosphatase non-receptor type 18
  • Downregulation of ERBB2 signaling
  • Interleukin-37 signaling
ACKR4 atypical chemokine receptor 4
  • Chemokine receptors bind chemokines
ACTL6A actin like 6A
  • HATs acetylate histones
  • RMTs methylate histone arginines
  • UCH proteinases
  • DNA Damage Recognition in GG-NER
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Regulation of MITF-M-dependent genes involved in pigmentation
  • Regulation of MITF-M-dependent genes involved in pigmentation
  • Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
  • Formation of the canonical BAF (cBAF) complex
  • Formation of the polybromo-BAF (pBAF) complex
  • Formation of the embryonic stem cell BAF (esBAF) complex
  • Formation of the non-canonical BAF (ncBAF) complex
  • Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
  • Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
ARID4A AT-rich interaction domain 4A
  • HDACs deacetylate histones
  • Potential therapeutics for SARS
ASB7 ankyrin repeat and SOCS box containing 7
  • Neddylation
  • Antigen processing: Ubiquitination & Proteasome degradation
BARD1 BRCA1 associated RING domain 1
  • HDR through Single Strand Annealing (SSA)
  • HDR through Homologous Recombination (HRR)
  • UCH proteinases
  • Metalloprotease DUBs
  • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Nonhomologous End-Joining (NHEJ)
  • Homologous DNA Pairing and Strand Exchange
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Defective DNA double strand break response due to BRCA1 loss of function
  • Defective DNA double strand break response due to BARD1 loss of function
  • Defective homologous recombination repair (HRR) due to BRCA1 loss of function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
  • Impaired BRCA2 binding to RAD51
  • Impaired BRCA2 binding to PALB2
BCL2 BCL2 apoptosis regulator
  • Activation of BAD and translocation to mitochondria
  • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
  • Interleukin-4 and Interleukin-13 signaling
  • The NLRP1 inflammasome
  • Estrogen-dependent gene expression
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • NFE2L2 regulating tumorigenic genes
  • Regulation of MITF-M-dependent genes involved in apoptosis
  • Ibuprofen
  • Paclitaxel
  • Docetaxel
  • Rasagiline
  • AN-9
  • Paclitaxel docosahexaenoic acid
  • Apoptone
  • Eribulin
  • Dexibuprofen
  • Venetoclax
  • Obatoclax
  • Navitoclax
  • Terpinen-4-ol
  • Oleandrin
  • Cervical cancer
  • Kaposi's sarcoma
  • Chronic lymphocytic leukemia (CLL)
  • Gastric cancer
  • Nasopharyngeal cancer
  • Choriocarcinoma
  • Small cell lung cancer
BRCA1 BRCA1 DNA repair associated
  • Meiotic synapsis
  • SUMOylation of DNA damage response and repair proteins
  • HDR through Single Strand Annealing (SSA)
  • HDR through Homologous Recombination (HRR)
  • Metalloprotease DUBs
  • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Nonhomologous End-Joining (NHEJ)
  • Homologous DNA Pairing and Strand Exchange
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • TP53 Regulates Transcription of DNA Repair Genes
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Neddylation
  • Transcriptional Regulation by E2F6
  • Meiotic recombination
  • Defective DNA double strand break response due to BRCA1 loss of function
  • Defective DNA double strand break response due to BARD1 loss of function
  • Defective homologous recombination repair (HRR) due to BRCA1 loss of function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
  • Impaired BRCA2 binding to RAD51
  • Impaired BRCA2 binding to PALB2
  • KEAP1-NFE2L2 pathway
  • Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
  • Ovarian cancer
  • Breast cancer

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