FXR1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
N4BP3	NEDD4 binding protein 3
NBPF15	NBPF member 15
NECAB2	N-terminal EF-hand calcium binding protein 2
NECAB3	N-terminal EF-hand calcium binding protein 3
NEFL	neurofilament light chain	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
NEIL3	nei like DNA glycosylase 3	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs
NKD2	NKD inhibitor of Wnt signaling pathway 2
NME1	NME/NM23 nucleoside diphosphate kinase 1	Interconversion of nucleotide di- and triphosphates Azathioprine ADME Ribavirin ADME	Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
NME1-NME2	NME1-NME2 readthrough
NME3	NME/NM23 nucleoside diphosphate kinase 3	Interconversion of nucleotide di- and triphosphates
PAFAH1B3	platelet activating factor acetylhydrolase 1b catalytic subunit 3	COPI-independent Golgi-to-ER retrograde traffic	(1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
PAICS	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Purine ribonucleoside monophosphate biosynthesis	Aspartic acid
PCCB	propionyl-CoA carboxylase subunit beta	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism Mitochondrial protein degradation	Biotin Valine	Propionic acidemia
PCED1A	PC-esterase domain containing 1A
PDE9A	phosphodiesterase 9A	cGMP effects	Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
PHC1P1	polyhomeotic homolog 1 pseudogene 1
PHC2	polyhomeotic homolog 2	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
PHLDB1	pleckstrin homology like domain family B member 1
PKM	pyruvate kinase M1/2	Neutrophil degranulation Negative Regulation of CDH1 Gene Transcription	Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Indoprofen Copper Polydatin Artenimol
PML	PML nuclear body scaffold	SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	Arsenic trioxide	Acute myeloid leukemia (AML)

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