Search Results for: brca1

323 interactions involving BRCA1 - BRCA1 DNA repair associated found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Symbol Description Pathways Hide Drugs Hide Diseases Hide
JUNB JunB proto-oncogene, AP-1 transcription factor subunit
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Interleukin-4 and Interleukin-13 signaling
  • NGF-stimulated transcription
  • NGF-stimulated transcription
  • Nuclear events stimulated by ALK signaling in cancer
JUND JunD proto-oncogene, AP-1 transcription factor subunit
  • Estrogen-dependent gene expression
  • NGF-stimulated transcription
  • NGF-stimulated transcription
  • Regulation of PD-L1(CD274) transcription
JUP junction plakoglobin
  • Adherens junctions interactions
  • VEGFR2 mediated vascular permeability
  • Neutrophil degranulation
  • Keratinization
  • Formation of the cornified envelope
  • RHOA GTPase cycle
  • RHOB GTPase cycle
  • RHOC GTPase cycle
  • CDC42 GTPase cycle
  • RHOQ GTPase cycle
  • RHOH GTPase cycle
  • RHOJ GTPase cycle
  • Regulation of CDH11 function
  • Regulation of CDH11 function
  • Regulation of CDH19 Expression and Function
  • Regulation of CDH1 Function
  • Degradation of CDH1
  • Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
  • CDH11 homotypic and heterotypic interactions
  • Zinc
  • Zinc acetate
  • Naxos disease and Carvajal syndrome
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KAT5 lysine acetyltransferase 5
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • DNA Damage/Telomere Stress Induced Senescence
  • HATs acetylate histones
  • HDR through Single Strand Annealing (SSA)
  • HDR through Homologous Recombination (HRR)
  • Sensing of DNA Double Strand Breaks
  • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Nonhomologous End-Joining (NHEJ)
  • Homologous DNA Pairing and Strand Exchange
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Estrogen-dependent gene expression
  • Defective homologous recombination repair (HRR) due to BRCA1 loss of function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
  • Impaired BRCA2 binding to RAD51
  • Impaired BRCA2 binding to PALB2
  • Cardiogenesis
  • Coenzyme A
  • S-Acetyl-Cysteine
KDM1A lysine demethylase 1A
  • HDACs deacetylate histones
  • HDMs demethylate histones
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • Regulation of PTEN gene transcription
  • Estrogen-dependent gene expression
  • NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
  • Potential therapeutics for SARS
  • Negative Regulation of CDH1 Gene Transcription
  • Factors involved in megakaryocyte development and platelet production
  • Vafidemstat
KIF1B kinesin family member 1B
  • COPI-dependent Golgi-to-ER retrograde traffic
  • Kinesins
  • Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
KPNA2 karyopherin subunit alpha 2
  • CaMK IV-mediated phosphorylation of CREB
  • ISG15 antiviral mechanism
  • NS1 Mediated Effects on Host Pathways
  • CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
  • Sensing of DNA Double Strand Breaks
  • Estrogen-dependent gene expression
  • SARS-CoV-1 activates/modulates innate immune responses
  • SARS-CoV-2 activates/modulates innate and adaptive immune responses
KPNA6 karyopherin subunit alpha 6
  • Assembly of the ORC complex at the origin of replication
LARP7 La ribonucleoprotein 7, transcriptional regulator
LCK LCK proto-oncogene, Src family tyrosine kinase
  • GPVI-mediated activation cascade
  • PIP3 activates AKT signaling
  • Signaling by SCF-KIT
  • Signaling by SCF-KIT
  • Regulation of KIT signaling
  • Nef and signal transduction
  • Nef Mediated CD4 Down-regulation
  • Downstream TCR signaling
  • Phosphorylation of CD3 and TCR zeta chains
  • Translocation of ZAP-70 to Immunological synapse
  • Generation of second messenger molecules
  • PECAM1 interactions
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • DAP12 signaling
  • DAP12 signaling
  • Co-stimulation by CD28
  • CD28 dependent PI3K/Akt signaling
  • CD28 dependent Vav1 pathway
  • Co-inhibition by CTLA4
  • Co-inhibition by PD-1
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • RHOH GTPase cycle
  • Interleukin-2 signaling
  • Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
  • FLT3 signaling through SRC family kinases
  • Dasatinib
  • AP-22408
  • Staurosporine
  • 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
  • {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid
  • Phosphoaminophosphonic Acid-Adenylate Ester
  • 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
  • 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
  • 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
  • N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
  • N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
  • N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
  • Ponatinib
  • Nintedanib
  • Fostamatinib
  • Zanubrutinib
  • Zotiraciclib
  • Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
LCMT1 leucine carboxyl methyltransferase 1
  • Cyclin A/B1/B2 associated events during G2/M transition
  • Leucine
LDHC lactate dehydrogenase C
  • Pyruvate metabolism
  • NADH
LMNTD1 lamin tail domain containing 1
LMO4 LIM domain only 4
LONRF1 LON peptidase N-terminal domain and ring finger 1
  • Antigen processing: Ubiquitination & Proteasome degradation
MACROH2A1 macroH2A.1 histone
MAN2C1 mannosidase alpha class 2C member 1
  • Lysosomal oligosaccharide catabolism
MAP3K1 mitogen-activated protein kinase kinase kinase 1
  • MyD88:MAL(TIRAP) cascade initiated on plasma membrane
  • FCERI mediated MAPK activation
  • FCERI mediated MAPK activation
  • TRAF6 mediated NF-kB activation
  • TRAF6 mediated NF-kB activation
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
  • MyD88 cascade initiated on plasma membrane
  • AZD-8330
  • Binimetinib
  • Fostamatinib
MAP3K14 mitogen-activated protein kinase kinase kinase 14
  • CD28 dependent PI3K/Akt signaling
  • Dectin-1 mediated noncanonical NF-kB signaling
  • TNFR2 non-canonical NF-kB pathway
  • NIK-->noncanonical NF-kB signaling
  • TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
MAP3K3 mitogen-activated protein kinase kinase kinase 3
  • Interleukin-1 signaling
  • Fostamatinib

Page 8 out of 17 pages