Search Results for: TSC1

180 interactions involving TSC1 - TSC complex subunit 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
SH2D2A SH2 domain containing 2A
  • VEGFA-VEGFR2 Pathway
SHANK1 SH3 and multiple ankyrin repeat domains 1
  • Neurexins and neuroligins
  • Neurexins and neuroligins
SHC3 SHC adaptor protein 3
  • Signalling to RAS
  • Signalling to RAS
  • RAF/MAP kinase cascade
  • RET signaling
SMG9 SMG9 nonsense mediated mRNA decay factor
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SORBS3 sorbin and SH3 domain containing 3
  • Smooth Muscle Contraction
SOX4 SRY-box transcription factor 4
  • Deactivation of the beta-catenin transactivating complex
SPAG5 sperm associated antigen 5
SPAG8 sperm associated antigen 8
SUOX sulfite oxidase
  • Sulfide oxidation to sulfate
  • {[2-Amino-4-oxo-6,7-di(sulfanyl-κS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)sulfanylmolybdenum
TANK TRAF family member associated NFKB activator
  • TICAM1-dependent activation of IRF3/IRF7
  • TRAF6 mediated IRF7 activation
  • Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
  • Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
  • Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
TBC1D7 TBC1 domain family member 7
  • TBC/RABGAPs
TBX6 T-box transcription factor 6
  • Formation of paraxial mesoderm
  • Somitogenesis
  • Formation of the posterior neural plate
TCF7L2 transcription factor 7 like 2
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • Deactivation of the beta-catenin transactivating complex
  • Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
  • Ca2+ pathway
  • Binding of TCF/LEF:CTNNB1 to target gene promoters
  • Repression of WNT target genes
  • Repression of WNT target genes
  • Signaling by TCF7L2 mutants
  • Transcriptional Regulation by VENTX
  • RUNX3 regulates WNT signaling
  • Formation of definitive endoderm
  • Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
  • Regulation of PD-L1(CD274) transcription
  • Type II diabetes mellitus
TFAP2D transcription factor AP-2 delta
  • Negative regulation of activity of TFAP2 (AP-2) family transcription factors
  • Negative regulation of activity of TFAP2 (AP-2) family transcription factors
  • Activation of the TFAP2 (AP-2) family of transcription factors
TFIP11 tuftelin interacting protein 11
  • mRNA Splicing - Major Pathway
TLE5 TLE family member 5, transcriptional modulator
  • Repression of WNT target genes
TNS2 tensin 2
TRIM3 tripartite motif containing 3
  • Interferon gamma signaling
TRIOBP TRIO and F-actin binding protein
TSC2 TSC complex subunit 2
  • Macroautophagy
  • Inhibition of TSC complex formation by PKB
  • AKT phosphorylates targets in the cytosol
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • TP53 Regulates Metabolic Genes
  • Constitutive Signaling by AKT1 E17K in Cancer
  • TBC/RABGAPs
  • Lymphangioleiomyomatosis (LAM)
  • Tuberous sclerosis complex (TSC); Bourneville-Pringle disease

Page 8 out of 9 pages