TCF4 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NUDT22	nudix hydrolase 22
NXPE2	neurexophilin and PC-esterase domain family member 2
NXT2	nuclear transport factor 2 like export factor 2
OLFM3	olfactomedin 3
ORC4	origin recognition complex subunit 4	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
OSGIN1	oxidative stress induced growth inhibitor 1
OTUD4	OTU deubiquitinase 4
PARP1	poly(ADP-ribose) polymerase 1	POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
PATE1	prostate and testis expressed 1
PBLD	phenazine biosynthesis like protein domain containing
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE
PLEKHN1	pleckstrin homology domain containing N1
POLR1A	RNA polymerase I subunit A	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
POLR1C	RNA polymerase I and III subunit C	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter		Treacher Collins syndrome
PPIA	peptidylprolyl isomerase A	Platelet degranulation Uncoating of the HIV Virion Budding and maturation of HIV virion Integration of provirus Early Phase of HIV Life Cycle Minus-strand DNA synthesis Plus-strand DNA synthesis Binding and entry of HIV virion Assembly Of The HIV Virion APOBEC3G mediated resistance to HIV-1 infection Calcineurin activates NFAT Basigin interactions Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation SARS-CoV-1 activates/modulates innate immune responses	Cyclosporine Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate Sanglifehrin A Copper Artenimol
PPIL1	peptidylprolyl isomerase like 1	mRNA Splicing - Major Pathway
PPP1R18	protein phosphatase 1 regulatory subunit 18
PRKAA2	protein kinase AMP-activated catalytic subunit alpha 2	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs Nuclear events mediated by NFE2L2 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Adenosine phosphate Acetylsalicylic acid Fostamatinib
PRKAB2	protein kinase AMP-activated non-catalytic subunit beta 2	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Adenosine phosphate Acetylsalicylic acid Fostamatinib
PRKN	parkin RBR E3 ubiquitin protein ligase	PINK1-PRKN Mediated Mitophagy Regulation of necroptotic cell death Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation		Parkinson's disease (PD)

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