PLEKHF2 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SPEF1	sperm flagellar 1
SPON2	spondin 2	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
STAMBPL1	STAM binding protein like 1	Metalloprotease DUBs
SYT16	synaptotagmin 16
TBCEL	tubulin folding cofactor E like
TBX3	T-box transcription factor 3	Transcriptional and post-translational regulation of MITF-M expression and activity		Ulnar-mammary syndrome; Schinzel syndrome
TCEANC	transcription elongation factor A N-terminal and central domain containing
THAP10	THAP domain containing 10
THG1L	tRNA-histidine guanylyltransferase 1 like	tRNA modification in the nucleus and cytosol
TNFAIP8	TNF alpha induced protein 8	PI Metabolism
TNFAIP8L1	TNF alpha induced protein 8 like 1	PI Metabolism
TP53BP2	tumor protein p53 binding protein 2	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
TRAF6	TNF receptor associated factor 6	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane
TRAM1L1	translocation associated membrane protein 1 like 1
TRAPPC3	trafficking protein particle complex subunit 3	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	Palmitic Acid Myristic acid S-palmitoyl-L-cysteine
TRIAP1	TP53 regulated inhibitor of apoptosis 1	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Mitochondrial protein degradation
TRIM22	tripartite motif containing 22	Interferon gamma signaling
TSC22D3	TSC22 domain family member 3	Stimuli-sensing channels
TTC9C	tetratricopeptide repeat domain 9C
TXNL4B	thioredoxin like 4B

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