TLE5 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HEXIM2	HEXIM P-TEFb complex subunit 2
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Citric acid
HHEX	hematopoietically expressed homeobox	Developmental Lineage of Multipotent Pancreatic Progenitor Cells		Type II diabetes mellitus
HMGB1	high mobility group box 1	ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1-dependent IKK and NF-kappa-B activation MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Chloroquine Ethyl pyruvate
HNF1A	HNF1 homeobox A	Regulation of gene expression in beta cells	D-norleucine	Maturity onset diabetes of the young (MODY)
HNRNPF	heterogeneous nuclear ribonucleoprotein F	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Phenethyl Isothiocyanate
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
HNRNPK	heterogeneous nuclear ribonucleoprotein K	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events	Artenimol Phenethyl Isothiocyanate
HNRNPLL	heterogeneous nuclear ribonucleoprotein L like
HOMEZ	homeobox and leucine zipper encoding
HOXA1	homeobox A1	Activation of anterior HOX genes in hindbrain development during early embryogenesis		Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome
HOXB5	homeobox B5
HOXC8	homeobox C8	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription
HOXC9	homeobox C9
IKZF3	IKAROS family zinc finger 3
INO80B	INO80 complex subunit B	UCH proteinases DNA Damage Recognition in GG-NER
INO80E	INO80 complex subunit E	UCH proteinases DNA Damage Recognition in GG-NER
INPP5J	inositol polyphosphate-5-phosphatase J	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
IRX2	iroquois homeobox 2	Nephron development
IRX6	iroquois homeobox 6

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