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UBE2L3 |
ubiquitin conjugating enzyme E2 L3 |
- PINK1-PRKN Mediated Mitophagy
- Regulation of TNFR1 signaling
- Regulation of necroptotic cell death
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2L6 |
ubiquitin conjugating enzyme E2 L6 |
- ISG15 antiviral mechanism
- DDX58/IFIH1-mediated induction of interferon-alpha/beta
- Termination of translesion DNA synthesis
- Negative regulators of DDX58/IFIH1 signaling
- Negative regulators of DDX58/IFIH1 signaling
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
- RSV-host interactions
- PKR-mediated signaling
- Modulation of host responses by IFN-stimulated genes
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UBE2M |
ubiquitin conjugating enzyme E2 M |
- TGF-beta receptor signaling activates SMADs
- Dectin-1 mediated noncanonical NF-kB signaling
- NIK-->noncanonical NF-kB signaling
- Neddylation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2N |
ubiquitin conjugating enzyme E2 N |
- ISG15 antiviral mechanism
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1-dependent IKK and NF-kappa-B activation
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- PINK1-PRKN Mediated Mitophagy
- CLEC7A (Dectin-1) signaling
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- E3 ubiquitin ligases ubiquitinate target proteins
- Interleukin-1 signaling
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- Aggrephagy
- Aggrephagy
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2R2 |
ubiquitin conjugating enzyme E2 R2 |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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VHL |
von Hippel-Lindau tumor suppressor |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- SUMOylation of ubiquitinylation proteins
- Neddylation
- Replication of the SARS-CoV-1 genome
- Replication of the SARS-CoV-2 genome
- RHOBTB3 ATPase cycle
- Antigen processing: Ubiquitination & Proteasome degradation
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- von Hippel-Lindau syndrome
- Congenital polycythemia; Familial erythrocytosis (ECYT)
- Renal cell carcinoma
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VRK2 |
VRK serine/threonine kinase 2 |
- RAC1 GTPase cycle
- RAC2 GTPase cycle
- RHOD GTPase cycle
- RHOG GTPase cycle
- RAC3 GTPase cycle
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