FXR1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ECHS1	enoyl-CoA hydratase, short chain 1	Branched-chain amino acid catabolism Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA Mitochondrial short-chain enoyl-CoA hydratase deficiency 1	Hexanoyl-CoA Octanoyl-Coenzyme A Acetoacetyl-CoA 4-(N,N-Dimethylamino)cinnamoyl-CoA Omega-3-carboxylic acids
ECM1	extracellular matrix protein 1	Platelet degranulation		Lipoid proteinosis; Urbach-Wiethe disease
EDC4	enhancer of mRNA decapping 4	mRNA decay by 5' to 3' exoribonuclease
EFEMP2	EGF-like fibulin extracellular matrix protein 2	Molecules associated with elastic fibres Molecules associated with elastic fibres		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
EGFL7	EGF like domain multiple 7
EIF3A	eukaryotic translation initiation factor 3 subunit A	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
ELOA	elongin A	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
ENO1	enolase 1	Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
ERCC6	ERCC excision repair 6, chromatin remodeling factor	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
ERG28	ergosterol biosynthesis 28 homolog
ERVFRD-1	endogenous retrovirus group FRD member 1, envelope
ESCO2	establishment of sister chromatid cohesion N-acetyltransferase 2	Establishment of Sister Chromatid Cohesion		ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
EVL	Enah/Vasp-like	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
FAM161A	FAM161 centrosomal protein A			Retinitis pigmentosa (RP)
FAM90A1	family with sequence similarity 90 member A1
FBLN1	fibulin 1	Molecules associated with elastic fibres Molecules associated with elastic fibres		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
FLAD1	flavin adenine dinucleotide synthetase 1	Vitamin B2 (riboflavin) metabolism
FLNB	filamin B	ISG15 antiviral mechanism		FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome Spondylocarpotarsal synostosis syndrome
FMR1	fragile X messenger ribonucleoprotein 1			Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)
FTH1	ferritin heavy chain 1	Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport	Iron Dextran Iron Ferric pyrophosphate citrate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate

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