Cancer - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols VHL and ZNF827	Name 1 von Hippel-Lindau tumor suppressor	Name2 zinc finger protein 827	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma	Diseases 2
Novel Novel	Symbols VHL and NR4A3	Name 1 von Hippel-Lindau tumor suppressor	Name2 nuclear receptor subfamily 4 group A member 3	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Drugs 1	Drugs 2 Dasatinib	Diseases 1 von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma	Diseases 2 Extraskeletal myxoid chondrosarcoma
Novel Novel	Symbols ZNF24 and ZGPAT	Name 1 zinc finger protein 24	Name2 zinc finger CCCH-type and G-patch domain containing	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols XPA and GPN1	Name 1 XPA, DNA damage recognition and repair factor	Name2 GPN-loop GTPase 1	Pathway 1 Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Diseases 2
Novel Novel	Symbols AGTR2 and PIK3CB	Name 1 angiotensin II receptor type 2	Name2 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Pathway 1 Peptide ligand-binding receptors G alpha (i) signalling events	Pathway 2 PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS	Drugs 1 Tasosartan CYT006-AngQb Olodanrigan	Drugs 2 Caffeine XL765	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2
Novel Novel	Symbols NONO and DELEC1	Name 1 non-POU domain containing octamer binding	Name2 deleted in esophageal cancer 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SMAD4 and NOTCH4	Name 1 SMAD family member 4	Name2 notch receptor 4	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2 Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel Novel	Symbols SMAD4 and TENM3	Name 1 SMAD family member 4	Name2 teneurin transmembrane protein 3	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel Novel	Symbols SMAD4 and ZNF521	Name 1 SMAD family member 4	Name2 zinc finger protein 521	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2 RUNX2 regulates osteoblast differentiation Formation of the anterior neural plate Formation of the posterior neural plate	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel Novel	Symbols SMAD4 and ARL5B	Name 1 SMAD family member 4	Name2 ARF like GTPase 5B	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2 Guanosine-5'-Diphosphate	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel Novel	Symbols SMAD4 and MEX3B	Name 1 SMAD family member 4	Name2 mex-3 RNA binding family member B	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel Novel	Symbols ACTN3 and PPP1R18	Name 1 actinin alpha 3	Name2 protein phosphatase 1 regulatory subunit 18	Pathway 1 Nephrin family interactions Striated Muscle Contraction	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ACTN3 and CTAG1B	Name 1 actinin alpha 3	Name2 cancer/testis antigen 1B	Pathway 1 Nephrin family interactions Striated Muscle Contraction	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ACTN3 and CTAG1A	Name 1 actinin alpha 3	Name2 cancer/testis antigen 1A	Pathway 1 Nephrin family interactions Striated Muscle Contraction	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CASK and CNTNAP2	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 contactin associated protein 2	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel Novel	Symbols CASK and NTN4	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 netrin 4	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2 Non-integrin membrane-ECM interactions Netrin-1 signaling	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel Novel	Symbols CASK and CADM1	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 cell adhesion molecule 1	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2 Adherens junctions interactions Nectin/Necl trans heterodimerization	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2 Nasopharyngeal cancer
Novel Novel	Symbols MAGED1 and LARP4B	Name 1 MAGE family member D1	Name2 La ribonucleoprotein 4B	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MAGED1 and NAF1	Name 1 MAGE family member D1	Name2 nuclear assembly factor 1 ribonucleoprotein	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MAGED1 and MGAT5B	Name 1 MAGE family member D1	Name2 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2 DAG1 core M2 glycosylations	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols VHL and ZNF827	Name 1 von Hippel-Lindau tumor suppressor	Name2 zinc finger protein 827	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma	Diseases 2
Novel	Symbols VHL and NR4A3	Name 1 von Hippel-Lindau tumor suppressor	Name2 nuclear receptor subfamily 4 group A member 3	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Drugs 1	Drugs 2 Dasatinib	Diseases 1 von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma	Diseases 2 Extraskeletal myxoid chondrosarcoma
Novel	Symbols ZNF24 and ZGPAT	Name 1 zinc finger protein 24	Name2 zinc finger CCCH-type and G-patch domain containing	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols XPA and GPN1	Name 1 XPA, DNA damage recognition and repair factor	Name2 GPN-loop GTPase 1	Pathway 1 Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Diseases 2
Novel	Symbols AGTR2 and PIK3CB	Name 1 angiotensin II receptor type 2	Name2 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Pathway 1 Peptide ligand-binding receptors G alpha (i) signalling events	Pathway 2 PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS	Drugs 1 Tasosartan CYT006-AngQb Olodanrigan	Drugs 2 Caffeine XL765	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2
Novel	Symbols NONO and DELEC1	Name 1 non-POU domain containing octamer binding	Name2 deleted in esophageal cancer 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SMAD4 and NOTCH4	Name 1 SMAD family member 4	Name2 notch receptor 4	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2 Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel	Symbols SMAD4 and TENM3	Name 1 SMAD family member 4	Name2 teneurin transmembrane protein 3	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel	Symbols SMAD4 and ZNF521	Name 1 SMAD family member 4	Name2 zinc finger protein 521	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2 RUNX2 regulates osteoblast differentiation Formation of the anterior neural plate Formation of the posterior neural plate	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel	Symbols SMAD4 and ARL5B	Name 1 SMAD family member 4	Name2 ARF like GTPase 5B	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2 Guanosine-5'-Diphosphate	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel	Symbols SMAD4 and MEX3B	Name 1 SMAD family member 4	Name2 mex-3 RNA binding family member B	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel	Symbols ACTN3 and PPP1R18	Name 1 actinin alpha 3	Name2 protein phosphatase 1 regulatory subunit 18	Pathway 1 Nephrin family interactions Striated Muscle Contraction	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ACTN3 and CTAG1B	Name 1 actinin alpha 3	Name2 cancer/testis antigen 1B	Pathway 1 Nephrin family interactions Striated Muscle Contraction	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ACTN3 and CTAG1A	Name 1 actinin alpha 3	Name2 cancer/testis antigen 1A	Pathway 1 Nephrin family interactions Striated Muscle Contraction	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CASK and CNTNAP2	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 contactin associated protein 2	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel	Symbols CASK and NTN4	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 netrin 4	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2 Non-integrin membrane-ECM interactions Netrin-1 signaling	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel	Symbols CASK and CADM1	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 cell adhesion molecule 1	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2 Adherens junctions interactions Nectin/Necl trans heterodimerization	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2 Nasopharyngeal cancer
Novel	Symbols MAGED1 and LARP4B	Name 1 MAGE family member D1	Name2 La ribonucleoprotein 4B	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MAGED1 and NAF1	Name 1 MAGE family member D1	Name2 nuclear assembly factor 1 ribonucleoprotein	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MAGED1 and MGAT5B	Name 1 MAGE family member D1	Name2 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2 DAG1 core M2 glycosylations	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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