Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols CLDN7 and EPCAM	Name 1 claudin 7	Name2 epithelial cell adhesion molecule	Pathway 1 Tight junction interactions	Pathway 2 Cell surface interactions at the vascular wall Attachment of bacteria to epithelial cells Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Drugs 1	Drugs 2 Oportuzumab monatox ING-1 Catumaxomab Technetium Tc-99m nofetumomab merpentan Hypromellose	Diseases 1	Diseases 2 Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Novel Novel	Symbols HOXA1 and PTH1R	Name 1 homeobox A1	Name2 parathyroid hormone 1 receptor	Pathway 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis	Pathway 2 Class B/2 (Secretin family receptors) G alpha (s) signalling events	Drugs 1	Drugs 2 Abaloparatide Parathyroid hormone Teriparatide	Diseases 1 Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome	Diseases 2 Eiken dysplasia Blomstrand syndrome; Blomstrand chondrodysplasia Primary failure of tooth eruption Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
Novel Novel	Symbols USHBP1 and CCDC42	Name 1 USH1 protein network component harmonin binding protein 1	Name2 coiled-coil domain containing 42	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BIRC2 and UBE2Q2	Name 1 baculoviral IAP repeat containing 2	Name2 ubiquitin conjugating enzyme E2 Q2	Pathway 1 Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	Pathway 2 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NTAQ1 and TRIM9	Name 1 N-terminal glutamine amidase 1	Name2 tripartite motif containing 9	Pathway 1	Pathway 2 Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NTAQ1 and ACOT13	Name 1 N-terminal glutamine amidase 1	Name2 acyl-CoA thioesterase 13	Pathway 1	Pathway 2 Mitochondrial Fatty Acid Beta-Oxidation	Drugs 1	Drugs 2 2-Undecanone	Diseases 1	Diseases 2
Novel Novel	Symbols NTAQ1 and GNPDA2	Name 1 N-terminal glutamine amidase 1	Name2 glucosamine-6-phosphate deaminase 2	Pathway 1	Pathway 2 Glycolysis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols STX8 and NCR3LG1	Name 1 syntaxin 8	Name2 natural killer cell cytotoxicity receptor 3 ligand 1	Pathway 1	Pathway 2 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SGTA and TMEM154	Name 1 small glutamine rich tetratricopeptide repeat co-chaperone alpha	Name2 transmembrane protein 154	Pathway 1 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SINHCAF and GTPBP3	Name 1 SIN3-HDAC complex associated factor	Name2 GTP binding protein 3, mitochondrial	Pathway 1	Pathway 2 tRNA modification in the mitochondrion	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TADA2A and MTX2	Name 1 transcriptional adaptor 2A	Name2 metaxin 2	Pathway 1 HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Pathway 2 Mitochondrial protein import Cristae formation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SRPK2 and ADAMTS18	Name 1 SRSF protein kinase 2	Name2 ADAM metallopeptidase with thrombospondin type 1 motif 18	Pathway 1 Maturation of nucleoprotein	Pathway 2 Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Drugs 1 Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SRPK2 and CHD1L	Name 1 SRSF protein kinase 2	Name2 chromodomain helicase DNA binding protein 1 like	Pathway 1 Maturation of nucleoprotein	Pathway 2 Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Drugs 1 Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SRPK2 and SEC16B	Name 1 SRSF protein kinase 2	Name2 SEC16 homolog B, endoplasmic reticulum export factor	Pathway 1 Maturation of nucleoprotein	Pathway 2 COPII-mediated vesicle transport	Drugs 1 Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SRPK2 and YTHDC2	Name 1 SRSF protein kinase 2	Name2 YTH N6-methyladenosine RNA binding protein C2	Pathway 1 Maturation of nucleoprotein	Pathway 2 Nuclear RNA decay	Drugs 1 Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ACTG1 and ST3GAL3	Name 1 actin gamma 1	Name2 ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Pathway 2 Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis Glycosphingolipid biosynthesis	Drugs 1 Copper Artenimol	Drugs 2	Diseases 1	Diseases 2 Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
Novel Novel	Symbols PTPN9 and SLC16A13	Name 1 protein tyrosine phosphatase non-receptor type 9	Name2 solute carrier family 16 member 13	Pathway 1 Interleukin-37 signaling	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MTUS2 and ZBTB38	Name 1 microtubule associated scaffold protein 2	Name2 zinc finger and BTB domain containing 38	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols EMD and CLEC14A	Name 1 emerin	Name2 C-type lectin domain containing 14A	Pathway 1 Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Pathway 2	Drugs 1	Drugs 2 Resveratrol	Diseases 1 Emery-Dreifuss muscular dystrophy	Diseases 2
Novel Novel	Symbols TEX11 and GRXCR1	Name 1 testis expressed 11	Name2 glutaredoxin and cysteine rich domain containing 1	Pathway 1	Pathway 2 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CLDN7 and EPCAM	Name 1 claudin 7	Name2 epithelial cell adhesion molecule	Pathway 1 Tight junction interactions	Pathway 2 Cell surface interactions at the vascular wall Attachment of bacteria to epithelial cells Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Drugs 1	Drugs 2 Oportuzumab monatox ING-1 Catumaxomab Technetium Tc-99m nofetumomab merpentan Hypromellose	Diseases 1	Diseases 2 Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Novel	Symbols HOXA1 and PTH1R	Name 1 homeobox A1	Name2 parathyroid hormone 1 receptor	Pathway 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis	Pathway 2 Class B/2 (Secretin family receptors) G alpha (s) signalling events	Drugs 1	Drugs 2 Abaloparatide Parathyroid hormone Teriparatide	Diseases 1 Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome	Diseases 2 Eiken dysplasia Blomstrand syndrome; Blomstrand chondrodysplasia Primary failure of tooth eruption Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
Novel	Symbols USHBP1 and CCDC42	Name 1 USH1 protein network component harmonin binding protein 1	Name2 coiled-coil domain containing 42	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BIRC2 and UBE2Q2	Name 1 baculoviral IAP repeat containing 2	Name2 ubiquitin conjugating enzyme E2 Q2	Pathway 1 Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	Pathway 2 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NTAQ1 and TRIM9	Name 1 N-terminal glutamine amidase 1	Name2 tripartite motif containing 9	Pathway 1	Pathway 2 Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NTAQ1 and ACOT13	Name 1 N-terminal glutamine amidase 1	Name2 acyl-CoA thioesterase 13	Pathway 1	Pathway 2 Mitochondrial Fatty Acid Beta-Oxidation	Drugs 1	Drugs 2 2-Undecanone	Diseases 1	Diseases 2
Novel	Symbols NTAQ1 and GNPDA2	Name 1 N-terminal glutamine amidase 1	Name2 glucosamine-6-phosphate deaminase 2	Pathway 1	Pathway 2 Glycolysis	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols STX8 and NCR3LG1	Name 1 syntaxin 8	Name2 natural killer cell cytotoxicity receptor 3 ligand 1	Pathway 1	Pathway 2 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SGTA and TMEM154	Name 1 small glutamine rich tetratricopeptide repeat co-chaperone alpha	Name2 transmembrane protein 154	Pathway 1 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SINHCAF and GTPBP3	Name 1 SIN3-HDAC complex associated factor	Name2 GTP binding protein 3, mitochondrial	Pathway 1	Pathway 2 tRNA modification in the mitochondrion	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TADA2A and MTX2	Name 1 transcriptional adaptor 2A	Name2 metaxin 2	Pathway 1 HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Pathway 2 Mitochondrial protein import Cristae formation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SRPK2 and ADAMTS18	Name 1 SRSF protein kinase 2	Name2 ADAM metallopeptidase with thrombospondin type 1 motif 18	Pathway 1 Maturation of nucleoprotein	Pathway 2 Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Drugs 1 Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SRPK2 and CHD1L	Name 1 SRSF protein kinase 2	Name2 chromodomain helicase DNA binding protein 1 like	Pathway 1 Maturation of nucleoprotein	Pathway 2 Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Drugs 1 Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SRPK2 and SEC16B	Name 1 SRSF protein kinase 2	Name2 SEC16 homolog B, endoplasmic reticulum export factor	Pathway 1 Maturation of nucleoprotein	Pathway 2 COPII-mediated vesicle transport	Drugs 1 Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SRPK2 and YTHDC2	Name 1 SRSF protein kinase 2	Name2 YTH N6-methyladenosine RNA binding protein C2	Pathway 1 Maturation of nucleoprotein	Pathway 2 Nuclear RNA decay	Drugs 1 Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ACTG1 and ST3GAL3	Name 1 actin gamma 1	Name2 ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Pathway 2 Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis Glycosphingolipid biosynthesis	Drugs 1 Copper Artenimol	Drugs 2	Diseases 1	Diseases 2 Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
Novel	Symbols PTPN9 and SLC16A13	Name 1 protein tyrosine phosphatase non-receptor type 9	Name2 solute carrier family 16 member 13	Pathway 1 Interleukin-37 signaling	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MTUS2 and ZBTB38	Name 1 microtubule associated scaffold protein 2	Name2 zinc finger and BTB domain containing 38	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols EMD and CLEC14A	Name 1 emerin	Name2 C-type lectin domain containing 14A	Pathway 1 Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Pathway 2	Drugs 1	Drugs 2 Resveratrol	Diseases 1 Emery-Dreifuss muscular dystrophy	Diseases 2
Novel	Symbols TEX11 and GRXCR1	Name 1 testis expressed 11	Name2 glutaredoxin and cysteine rich domain containing 1	Pathway 1	Pathway 2 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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