Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols TP53 and LACTB	Name 1 tumor protein p53	Name2 lactamase beta	Pathway 1 Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 Association of TriC/CCT with target proteins during biosynthesis Pyroptosis TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription Regulation of PTEN gene transcription Loss of function of TP53 in cancer due to loss of tetramerization ability Signaling by ALK fusions and activated point mutants Regulation of NF-kappa B signaling Zygotic genome activation (ZGA) Factors involved in megakaryocyte development and platelet production PKR-mediated signaling	Pathway 2	Drugs 1 Acetylsalicylic acid Zinc Triethyl phosphate AZD 3355 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Drugs 2	Diseases 1 Chronic myeloid leukemia (CML) Breast cancer Non-small cell lung cancer Gastric cancer Adult T-cell leukemia Choriocarcinoma Esophageal cancer Glioma Pancreatic cancer Vulvar cancer Multiple myeloma Choroid plexus papilloma Ovarian cancer Hepatocellular carcinoma Squamous cell carcinoma Endometrial Cancer Penile cancer Cancer of the anal canal Hairy-cell leukemia Oral cancer Adrenal carcinoma Malignant melanoma Burkitt lymphoma Thyroid cancer Basal cell carcinoma Small cell lung cancer Gallbladder cancer Bladder cancer Laryngeal cancer Kaposi's sarcoma Cholangiocarcinoma Chronic lymphocytic leukemia (CLL) Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL) Malignant pleural mesothelioma Osteosarcoma Colorectal cancer	Diseases 2
Novel Novel	Symbols PSMD2 and STEAP1	Name 1 proteasome 26S subunit ubiquitin receptor, non-ATPase 2	Name2 STEAP family member 1	Pathway 1 Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CDH1 and SFRP2	Name 1 cadherin 1	Name2 secreted frizzled related protein 2	Pathway 1 Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Pathway 2 TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Drugs 1	Drugs 2	Diseases 1 Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer	Diseases 2
Novel Novel	Symbols CDH1 and DNMT3A	Name 1 cadherin 1	Name2 DNA methyltransferase 3 alpha	Pathway 1 Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Pathway 2 PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Drugs 1	Drugs 2 Procaine Decitabine	Diseases 1 Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer	Diseases 2
Novel Novel	Symbols BIN1 and ITGA1	Name 1 bridging integrator 1	Name2 integrin subunit alpha 1	Pathway 1 Clathrin-mediated endocytosis	Pathway 2 Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen	Drugs 1	Drugs 2	Diseases 1 Centronuclear myopathy	Diseases 2
Novel Novel	Symbols BIN1 and XRCC4	Name 1 bridging integrator 1	Name2 X-ray repair cross complementing 4	Pathway 1 Clathrin-mediated endocytosis	Pathway 2 2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)	Drugs 1	Drugs 2 S-(Dimethylarsenic)Cysteine	Diseases 1 Centronuclear myopathy	Diseases 2
Novel Novel	Symbols BIN1 and PTGER4	Name 1 bridging integrator 1	Name2 prostaglandin E receptor 4	Pathway 1 Clathrin-mediated endocytosis	Pathway 2 Prostanoid ligand receptors G alpha (s) signalling events	Drugs 1	Drugs 2 Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost	Diseases 1 Centronuclear myopathy	Diseases 2
Novel Novel	Symbols VHL and LANCL1	Name 1 von Hippel-Lindau tumor suppressor	Name2 LanC like glutathione S-transferase 1	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma	Diseases 2
Novel Novel	Symbols VHL and NR4A3	Name 1 von Hippel-Lindau tumor suppressor	Name2 nuclear receptor subfamily 4 group A member 3	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Drugs 1	Drugs 2 Dasatinib	Diseases 1 von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma	Diseases 2 Extraskeletal myxoid chondrosarcoma
Novel Novel	Symbols XPA and PRDM16	Name 1 XPA, DNA damage recognition and repair factor	Name2 PR/SET domain 16	Pathway 1 Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Pathway 2 PKMTs methylate histone lysines Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Drugs 1	Drugs 2	Diseases 1 Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Diseases 2
Novel Novel	Symbols RAD23A and ZFAND6	Name 1 RAD23 nucleotide excision repair protein A	Name2 zinc finger AN1-type containing 6	Pathway 1 Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	Pathway 2 Peroxisomal protein import Peroxisomal protein import	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CASR and FLNA	Name 1 calcium sensing receptor	Name2 filamin A	Pathway 1 G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Pathway 2 Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	Drugs 1 Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate	Drugs 2 Artenimol	Diseases 1 Bartter syndrome	Diseases 2 FG syndrome (FGS); Opitz-Kaveggia syndrome Periventricular nodular heterotopia (PVNH) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Novel Novel	Symbols AGTR2 and MTUS1	Name 1 angiotensin II receptor type 2	Name2 microtubule associated scaffold protein 1	Pathway 1 Peptide ligand-binding receptors G alpha (i) signalling events	Pathway 2	Drugs 1 Tasosartan CYT006-AngQb Olodanrigan	Drugs 2	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2
Novel Novel	Symbols AGTR2 and ACE	Name 1 angiotensin II receptor type 2	Name2 angiotensin I converting enzyme	Pathway 1 Peptide ligand-binding receptors G alpha (i) signalling events	Pathway 2 Metabolism of Angiotensinogen to Angiotensins	Drugs 1 Tasosartan CYT006-AngQb Olodanrigan	Drugs 2 Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril Epicaptopril N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril Cilazaprilat	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2 Allograft rejection Renal tubular dysgenesis
Novel Novel	Symbols SMAD4 and NOTCH4	Name 1 SMAD family member 4	Name2 notch receptor 4	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2 Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel Novel	Symbols SMAD4 and TENM3	Name 1 SMAD family member 4	Name2 teneurin transmembrane protein 3	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel Novel	Symbols SMAD4 and ARL5B	Name 1 SMAD family member 4	Name2 ARF like GTPase 5B	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2 Guanosine-5'-Diphosphate	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel Novel	Symbols CASK and CNTNAP2	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 contactin associated protein 2	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel Novel	Symbols CASK and ELL2	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 elongation factor for RNA polymerase II 2	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2 RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel Novel	Symbols CASK and CADM1	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 cell adhesion molecule 1	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2 Adherens junctions interactions Nectin/Necl trans heterodimerization	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2 Nasopharyngeal cancer
Novel	Symbols TP53 and LACTB	Name 1 tumor protein p53	Name2 lactamase beta	Pathway 1 Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 Association of TriC/CCT with target proteins during biosynthesis Pyroptosis TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription Regulation of PTEN gene transcription Loss of function of TP53 in cancer due to loss of tetramerization ability Signaling by ALK fusions and activated point mutants Regulation of NF-kappa B signaling Zygotic genome activation (ZGA) Factors involved in megakaryocyte development and platelet production PKR-mediated signaling	Pathway 2	Drugs 1 Acetylsalicylic acid Zinc Triethyl phosphate AZD 3355 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Drugs 2	Diseases 1 Chronic myeloid leukemia (CML) Breast cancer Non-small cell lung cancer Gastric cancer Adult T-cell leukemia Choriocarcinoma Esophageal cancer Glioma Pancreatic cancer Vulvar cancer Multiple myeloma Choroid plexus papilloma Ovarian cancer Hepatocellular carcinoma Squamous cell carcinoma Endometrial Cancer Penile cancer Cancer of the anal canal Hairy-cell leukemia Oral cancer Adrenal carcinoma Malignant melanoma Burkitt lymphoma Thyroid cancer Basal cell carcinoma Small cell lung cancer Gallbladder cancer Bladder cancer Laryngeal cancer Kaposi's sarcoma Cholangiocarcinoma Chronic lymphocytic leukemia (CLL) Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL) Malignant pleural mesothelioma Osteosarcoma Colorectal cancer	Diseases 2
Novel	Symbols PSMD2 and STEAP1	Name 1 proteasome 26S subunit ubiquitin receptor, non-ATPase 2	Name2 STEAP family member 1	Pathway 1 Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CDH1 and SFRP2	Name 1 cadherin 1	Name2 secreted frizzled related protein 2	Pathway 1 Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Pathway 2 TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Drugs 1	Drugs 2	Diseases 1 Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer	Diseases 2
Novel	Symbols CDH1 and DNMT3A	Name 1 cadherin 1	Name2 DNA methyltransferase 3 alpha	Pathway 1 Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Pathway 2 PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Drugs 1	Drugs 2 Procaine Decitabine	Diseases 1 Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer	Diseases 2
Novel	Symbols BIN1 and ITGA1	Name 1 bridging integrator 1	Name2 integrin subunit alpha 1	Pathway 1 Clathrin-mediated endocytosis	Pathway 2 Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen	Drugs 1	Drugs 2	Diseases 1 Centronuclear myopathy	Diseases 2
Novel	Symbols BIN1 and XRCC4	Name 1 bridging integrator 1	Name2 X-ray repair cross complementing 4	Pathway 1 Clathrin-mediated endocytosis	Pathway 2 2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)	Drugs 1	Drugs 2 S-(Dimethylarsenic)Cysteine	Diseases 1 Centronuclear myopathy	Diseases 2
Novel	Symbols BIN1 and PTGER4	Name 1 bridging integrator 1	Name2 prostaglandin E receptor 4	Pathway 1 Clathrin-mediated endocytosis	Pathway 2 Prostanoid ligand receptors G alpha (s) signalling events	Drugs 1	Drugs 2 Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost	Diseases 1 Centronuclear myopathy	Diseases 2
Novel	Symbols VHL and LANCL1	Name 1 von Hippel-Lindau tumor suppressor	Name2 LanC like glutathione S-transferase 1	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma	Diseases 2
Novel	Symbols VHL and NR4A3	Name 1 von Hippel-Lindau tumor suppressor	Name2 nuclear receptor subfamily 4 group A member 3	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Drugs 1	Drugs 2 Dasatinib	Diseases 1 von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma	Diseases 2 Extraskeletal myxoid chondrosarcoma
Novel	Symbols XPA and PRDM16	Name 1 XPA, DNA damage recognition and repair factor	Name2 PR/SET domain 16	Pathway 1 Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Pathway 2 PKMTs methylate histone lysines Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Drugs 1	Drugs 2	Diseases 1 Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Diseases 2
Novel	Symbols RAD23A and ZFAND6	Name 1 RAD23 nucleotide excision repair protein A	Name2 zinc finger AN1-type containing 6	Pathway 1 Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	Pathway 2 Peroxisomal protein import Peroxisomal protein import	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CASR and FLNA	Name 1 calcium sensing receptor	Name2 filamin A	Pathway 1 G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Pathway 2 Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	Drugs 1 Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate	Drugs 2 Artenimol	Diseases 1 Bartter syndrome	Diseases 2 FG syndrome (FGS); Opitz-Kaveggia syndrome Periventricular nodular heterotopia (PVNH) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Novel	Symbols AGTR2 and MTUS1	Name 1 angiotensin II receptor type 2	Name2 microtubule associated scaffold protein 1	Pathway 1 Peptide ligand-binding receptors G alpha (i) signalling events	Pathway 2	Drugs 1 Tasosartan CYT006-AngQb Olodanrigan	Drugs 2	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2
Novel	Symbols AGTR2 and ACE	Name 1 angiotensin II receptor type 2	Name2 angiotensin I converting enzyme	Pathway 1 Peptide ligand-binding receptors G alpha (i) signalling events	Pathway 2 Metabolism of Angiotensinogen to Angiotensins	Drugs 1 Tasosartan CYT006-AngQb Olodanrigan	Drugs 2 Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril Epicaptopril N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril Cilazaprilat	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2 Allograft rejection Renal tubular dysgenesis
Novel	Symbols SMAD4 and NOTCH4	Name 1 SMAD family member 4	Name2 notch receptor 4	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2 Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel	Symbols SMAD4 and TENM3	Name 1 SMAD family member 4	Name2 teneurin transmembrane protein 3	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel	Symbols SMAD4 and ARL5B	Name 1 SMAD family member 4	Name2 ARF like GTPase 5B	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Pathway 2	Drugs 1	Drugs 2 Guanosine-5'-Diphosphate	Diseases 1 Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer	Diseases 2
Novel	Symbols CASK and CNTNAP2	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 contactin associated protein 2	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel	Symbols CASK and ELL2	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 elongation factor for RNA polymerase II 2	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2 RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2
Novel	Symbols CASK and CADM1	Name 1 calcium/calmodulin dependent serine protein kinase	Name2 cell adhesion molecule 1	Pathway 1 Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Pathway 2 Adherens junctions interactions Nectin/Necl trans heterodimerization	Drugs 1 Formic acid Fostamatinib	Drugs 2	Diseases 1 FG syndrome (FGS); Opitz-Kaveggia syndrome	Diseases 2 Nasopharyngeal cancer

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