RBX1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
KCTD17	potassium channel tetramerization domain containing 17
KEAP1	kelch like ECH associated protein 1	Ub-specific processing proteases Neddylation Potential therapeutics for SARS KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation	Dimethyl fumarate
KLHDC2	kelch domain containing 2
KLHL22	kelch like family member 22	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
KLHL3	kelch like family member 3	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
KPNB1	karyopherin subunit beta 1	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production SARS-CoV-1 activates/modulates innate immune responses Maturation of hRSV A proteins
KRTAP12-2	keratin associated protein 12-2	Keratinization
MAGEC2	MAGE family member C2
MAP3K20	mitogen-activated protein kinase kinase kinase 20		Dasatinib Fostamatinib
MAP3K7	mitogen-activated protein kinase kinase kinase 7	Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2
MKNK2	MAPK interacting serine/threonine kinase 2		Fostamatinib
MYB	MYB proto-oncogene, transcription factor	RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production Specification of the neural plate border
NEURL2	neuralized E3 ubiquitin protein ligase 2	Neddylation
OS9	OS9 endoplasmic reticulum lectin	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
PBX4	PBX homeobox 4
PML	PML nuclear body scaffold	SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	Arsenic trioxide	Acute myeloid leukemia (AML)
PRAME	PRAME nuclear receptor transcriptional regulator
RHOBTB3	Rho related BTB domain containing 3	Retrograde transport at the Trans-Golgi-Network RHOBTB3 ATPase cycle
RNF126	ring finger protein 126	Antigen processing: Ubiquitination & Proteasome degradation

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