SRPK2 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
TXN	thioredoxin	Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection NFE2L2 regulating anti-oxidant/detoxification enzymes	Phenethyl Isothiocyanate
U2AF1	U2 small nuclear RNA auxiliary factor 1	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
U2AF2	U2 small nuclear RNA auxiliary factor 2	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Protein hydroxylation
UBD	ubiquitin like modifier D	Neddylation
UBE2E2	ubiquitin conjugating enzyme E2 E2	Antigen processing: Ubiquitination & Proteasome degradation
UBR4	ubiquitin protein ligase E3 component n-recognin 4	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Verpasep caltespen Picolinic acid
UNKL	unk like zinc finger	Antigen processing: Ubiquitination & Proteasome degradation
UPF3B	UPF3B regulator of nonsense mediated mRNA decay	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
USP39	ubiquitin specific peptidase 39	mRNA Splicing - Major Pathway
VAC14	VAC14 component of PIKFYVE complex	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
VAV2	vav guanine nucleotide exchange factor 2	GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME
VRK1	VRK serine/threonine kinase 1	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation		Pontocerebellar hypoplasia
VSTM2L	V-set and transmembrane domain containing 2 like
WDR24	WD repeat domain 24	Amino acids regulate mTORC1
WDR5	WD repeat domain 5	PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation Cardiogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
WDR70	WD repeat domain 70	mRNA Splicing - Major Pathway
XRCC5	X-ray repair cross complementing 5	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
YBX3	Y-box binding protein 3
YPEL2	yippee like 2
YPEL3	yippee like 3

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