Search Results for: TRAF1

249 interactions involving TRAF1 - TNF receptor associated factor 1 found:

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Novel Symbol Description Pathways Hide Drugs Hide Diseases Hide
BIRC3 baculoviral IAP repeat containing 3
  • NOD1/2 Signaling Pathway
  • TICAM1, RIP1-mediated IKK complex recruitment
  • RIPK1-mediated regulated necrosis
  • TNFR1-induced proapoptotic signaling
  • Regulation of TNFR1 signaling
  • TNFR1-induced NF-kappa-B signaling pathway
  • TNFR2 non-canonical NF-kB pathway
  • Regulation of necroptotic cell death
  • TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
  • Ub-specific processing proteases
  • IKK complex recruitment mediated by RIP1
C1orf216 chromosome 1 open reading frame 216
CARHSP1 calcium regulated heat stable protein 1
CASP10 caspase 10
  • TP53 Regulates Transcription of Caspase Activators and Caspases
  • FasL/ CD95L signaling
  • TRAIL signaling
  • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
  • Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
CASP3 caspase 3
  • Activation of caspases through apoptosome-mediated cleavage
  • SMAC (DIABLO) binds to IAPs
  • SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
  • Apoptotic cleavage of cellular proteins
  • SMAC, XIAP-regulated apoptotic response
  • Apoptosis induced DNA fragmentation
  • Degradation of the extracellular matrix
  • Signaling by Hippo
  • NADE modulates death signalling
  • Stimulation of the cell death response by PAK-2p34
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Apoptotic cleavage of cell adhesion proteins
  • Caspase activation via Dependence Receptors in the absence of ligand
  • Caspase activation via Dependence Receptors in the absence of ligand
  • Other interleukin signaling
  • Pyroptosis
  • CASP4-mediated substrate cleavage
  • CASP5-mediated substrate cleavage
  • Pamidronic acid
  • Acetylsalicylic acid
  • Minocycline
  • 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
  • Emricasan
  • Incadronic acid
  • 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
  • methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
  • 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
  • [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
  • 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
  • (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
  • (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
  • N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
  • Tributyrin
  • Oleandrin
  • PAC-1
  • Glycyrrhizic acid
CASP6 caspase 6
  • Apoptotic cleavage of cellular proteins
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Breakdown of the nuclear lamina
  • TP53 Regulates Transcription of Caspase Activators and Caspases
CASP8 caspase 8
  • Apoptotic cleavage of cellular proteins
  • Caspase activation via Death Receptors in the presence of ligand
  • NOD1/2 Signaling Pathway
  • TRIF-mediated programmed cell death
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Regulation by c-FLIP
  • RIPK1-mediated regulated necrosis
  • CASP8 activity is inhibited
  • TNFR1-induced proapoptotic signaling
  • Regulation of TNFR1 signaling
  • CLEC7A/inflammasome pathway
  • Regulation of necroptotic cell death
  • Dimerization of procaspase-8
  • Activation, myristolyation of BID and translocation to mitochondria
  • Apoptotic execution phase
  • FasL/ CD95L signaling
  • TRAIL signaling
  • TLR3-mediated TICAM1-dependent programmed cell death
  • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
  • Microbial modulation of RIPK1-mediated regulated necrosis
  • Defective RIPK1-mediated regulated necrosis
  • Regulation of NF-kappa B signaling
  • Trichostatin A
  • AN-9
  • Bryostatin 1
  • Bardoxolone
  • Oleandrin
  • Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
CATSPERT catsper channel auxiliary subunit tau
CCDC116 coiled-coil domain containing 116
CCDC120 coiled-coil domain containing 120
CCDC146 coiled-coil domain containing 146
CCDC185 coiled-coil domain containing 185
CCDC187 coiled-coil domain containing 187
  • RHOC GTPase cycle
CCDC198 coiled-coil domain containing 198
CCHCR1 coiled-coil alpha-helical rod protein 1
CD40 CD40 molecule
  • Lucatumumab
  • Dacetuzumab
  • Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
  • Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
CDCA3 cell division cycle associated 3
CDK18 cyclin dependent kinase 18
CDKN1A cyclin dependent kinase inhibitor 1A
  • SCF(Skp2)-mediated degradation of p27/p21
  • AKT phosphorylates targets in the cytosol
  • Senescence-Associated Secretory Phenotype (SASP)
  • DNA Damage/Telomere Stress Induced Senescence
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Interleukin-4 and Interleukin-13 signaling
  • TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
  • Cyclin E associated events during G1/S transition
  • Cyclin D associated events in G1
  • p53-Dependent G1 DNA Damage Response
  • Cyclin A:Cdk2-associated events at S phase entry
  • Transcriptional activation of cell cycle inhibitor p21
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • TFAP2 (AP-2) family regulates transcription of cell cycle factors
  • Transcriptional regulation by RUNX2
  • RUNX3 regulates CDKN1A transcription
  • Neddylation
  • Transcriptional regulation of granulopoiesis
  • FOXO-mediated transcription of cell cycle genes
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
  • STAT5 activation downstream of FLT3 ITD mutants
  • Signaling by FLT3 fusion proteins
  • Signaling by ALK fusions and activated point mutants
  • KEAP1-NFE2L2 pathway
  • Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
  • Valproic acid
  • Arsenic trioxide
  • Cervical cancer
CDKN2B cyclin dependent kinase inhibitor 2B
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • Oncogene Induced Senescence
  • Cyclin D associated events in G1
  • Type II diabetes mellitus
  • Osteosarcoma
  • Malignant pleural mesothelioma

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