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KMT2A |
lysine methyltransferase 2A |
- PKMTs methylate histone lysines
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Transcriptional regulation of granulopoiesis
- Formation of WDR5-containing histone-modifying complexes
- Regulation of PD-L1(CD274) transcription
- Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
- Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
- The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
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- Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
- Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
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PAF1 |
PAF1 component of Paf1/RNA polymerase II complex |
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Pre-transcription Events
- RNA Polymerase II Transcription Elongation
- E3 ubiquitin ligases ubiquitinate target proteins
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PLAU |
plasminogen activator, urokinase |
- Neutrophil degranulation
- Dissolution of Fibrin Clot
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- Amiloride
- 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide
- 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
- 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine
- 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine
- 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine
- 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- CRA_10655
- 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide
- 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide
- Benzamidine
- 4-Iodobenzo[B]Thiophene-2-Carboxamidine
- CRA_8696
- Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine
- 2-Amino-1H-benzimidazol-5-ol
- N-(1-adamantyl)-N'-(4-guanidinobenzyl)urea
- 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
- Thieno[2,3-B]Pyridine-2-Carboxamidine
- 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide
- [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine
- Fibrinolysin
- 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine
- 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE
- N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE
- 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE
- 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine
- (2R)-1-(2,6-dimethylphenoxy)propan-2-amine
- 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide
- 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
- 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE
- 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
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RNF2 |
ring finger protein 2 |
- Oxidative Stress Induced Senescence
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription cofactors
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA methylation proteins
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Transcriptional Regulation by E2F6
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TP53 |
tumor protein p53 |
- Activation of NOXA and translocation to mitochondria
- Activation of PUMA and translocation to mitochondria
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- Oncogene Induced Senescence
- DNA Damage/Telomere Stress Induced Senescence
- SUMOylation of transcription factors
- Autodegradation of the E3 ubiquitin ligase COP1
- Association of TriC/CCT with target proteins during biosynthesis
- Pyroptosis
- TP53 Regulates Metabolic Genes
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Interleukin-4 and Interleukin-13 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- TP53 Regulates Transcription of Caspase Activators and Caspases
- TP53 Regulates Transcription of Death Receptors and Ligands
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- Regulation of TP53 Expression
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Acetylation
- Regulation of TP53 Activity through Association with Co-factors
- Regulation of TP53 Activity through Methylation
- PI5P Regulates TP53 Acetylation
- G2/M DNA damage checkpoint
- G2/M Checkpoints
- Stabilization of p53
- Transcriptional activation of cell cycle inhibitor p21
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Transcriptional Regulation by VENTX
- RUNX3 regulates CDKN1A transcription
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Loss of function of TP53 in cancer due to loss of tetramerization ability
- Signaling by ALK fusions and activated point mutants
- Regulation of NF-kappa B signaling
- Zygotic genome activation (ZGA)
- Factors involved in megakaryocyte development and platelet production
- PKR-mediated signaling
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- Acetylsalicylic acid
- Zinc
- Triethyl phosphate
- AZD 3355
- 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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- Chronic myeloid leukemia (CML)
- Breast cancer
- Non-small cell lung cancer
- Gastric cancer
- Adult T-cell leukemia
- Choriocarcinoma
- Esophageal cancer
- Glioma
- Pancreatic cancer
- Vulvar cancer
- Multiple myeloma
- Choroid plexus papilloma
- Ovarian cancer
- Hepatocellular carcinoma
- Squamous cell carcinoma
- Endometrial Cancer
- Penile cancer
- Cancer of the anal canal
- Hairy-cell leukemia
- Oral cancer
- Adrenal carcinoma
- Malignant melanoma
- Burkitt lymphoma
- Thyroid cancer
- Basal cell carcinoma
- Small cell lung cancer
- Gallbladder cancer
- Bladder cancer
- Laryngeal cancer
- Kaposi's sarcoma
- Cholangiocarcinoma
- Chronic lymphocytic leukemia (CLL)
- Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
- Malignant pleural mesothelioma
- Osteosarcoma
- Colorectal cancer
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TP53BP1 |
tumor protein p53 binding protein 1 |
- SUMOylation of transcription factors
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- G2/M DNA damage checkpoint
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