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UBE2L3
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ubiquitin conjugating enzyme E2 L3 |
- PINK1-PRKN Mediated Mitophagy
- Regulation of TNFR1 signaling
- Regulation of necroptotic cell death
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2N
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ubiquitin conjugating enzyme E2 N |
- ISG15 antiviral mechanism
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1-dependent IKK and NF-kappa-B activation
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- PINK1-PRKN Mediated Mitophagy
- CLEC7A (Dectin-1) signaling
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- E3 ubiquitin ligases ubiquitinate target proteins
- Interleukin-1 signaling
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- Aggrephagy
- Aggrephagy
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2T
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ubiquitin conjugating enzyme E2 T |
- Fanconi Anemia Pathway
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
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UBE2W
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ubiquitin conjugating enzyme E2 W |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE3A
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ubiquitin protein ligase E3A |
- Antigen processing: Ubiquitination & Proteasome degradation
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- Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
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UBXN1
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UBX domain protein 1 |
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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USF2
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upstream transcription factor 2, c-fos interacting |
- Estrogen-dependent gene expression
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USH2A
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usherin |
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- Usher syndrome (US)
- Retinitis pigmentosa (RP)
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USP2
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ubiquitin specific peptidase 2 |
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
- Ub-specific processing proteases
- Regulation of TP53 Degradation
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VCP
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valosin containing protein |
- Translesion Synthesis by POLH
- HSF1 activation
- ABC-family proteins mediated transport
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Defective CFTR causes cystic fibrosis
- Josephin domain DUBs
- Ovarian tumor domain proteases
- Neutrophil degranulation
- E3 ubiquitin ligases ubiquitinate target proteins
- Protein methylation
- Neddylation
- RHOH GTPase cycle
- Aggrephagy
- Attachment and Entry
- Attachment and Entry
- KEAP1-NFE2L2 pathway
- AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
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- Phosphoaminophosphonic Acid-Adenylate Ester
- Phenethyl Isothiocyanate
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- Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
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VHL
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von Hippel-Lindau tumor suppressor |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- SUMOylation of ubiquitinylation proteins
- Neddylation
- Replication of the SARS-CoV-1 genome
- Replication of the SARS-CoV-2 genome
- RHOBTB3 ATPase cycle
- Antigen processing: Ubiquitination & Proteasome degradation
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- von Hippel-Lindau syndrome
- Congenital polycythemia; Familial erythrocytosis (ECYT)
- Renal cell carcinoma
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WDR6
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WD repeat domain 6 |
- RHOU GTPase cycle
- RHOV GTPase cycle
- RND3 GTPase cycle
- RND2 GTPase cycle
- RND1 GTPase cycle
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WNT2B
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Wnt family member 2B |
- WNT ligand biogenesis and trafficking
- WNT ligand biogenesis and trafficking
- Class B/2 (Secretin family receptors)
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WRN
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WRN RecQ like helicase |
- Processive synthesis on the C-strand of the telomere
- Removal of the Flap Intermediate from the C-strand
- SUMOylation of DNA damage response and repair proteins
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
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- Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
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XAF1
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XIAP associated factor 1 |
- Interferon alpha/beta signaling
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XIAP
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X-linked inhibitor of apoptosis |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC, XIAP-regulated apoptotic response
- Deactivation of the beta-catenin transactivating complex
- RIPK1-mediated regulated necrosis
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
- Regulation of necroptotic cell death
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Regulation of the apoptosome activity
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- 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
- Dequalinium
- N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
- AEG35156
- Terpinen-4-ol
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- Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
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XRCC1
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X-ray repair cross complementing 1 |
- Resolution of AP sites via the single-nucleotide replacement pathway
- APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
- HDR through MMEJ (alt-NHEJ)
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
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XRCC5
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X-ray repair cross complementing 5 |
- 2-LTR circle formation
- Cytosolic sensors of pathogen-associated DNA
- IRF3-mediated induction of type I IFN
- Nonhomologous End-Joining (NHEJ)
- Neutrophil degranulation
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YY1
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YY1 transcription factor |
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- UCH proteinases
- DNA Damage Recognition in GG-NER
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- Estrogen-dependent gene expression
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ZNF280D
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zinc finger protein 280D |
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