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SETD1A |
SET domain containing 1A, histone lysine methyltransferase |
- PKMTs methylate histone lysines
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- Formation of WDR5-containing histone-modifying complexes
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SIK2 |
salt inducible kinase 2 |
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SIRT1 |
sirtuin 1 |
- Regulation of HSF1-mediated heat shock response
- SIRT1 negatively regulates rRNA expression
- SIRT1 negatively regulates rRNA expression
- Regulation of FOXO transcriptional activity by acetylation
- Regulation of FOXO transcriptional activity by acetylation
- Heme signaling
- Negative Regulation of CDH1 Gene Transcription
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
- Regulation of MITF-M dependent genes involved in metabolism
- Transcriptional and post-translational regulation of MITF-M expression and activity
- Expression of BMAL (ARNTL), CLOCK, and NPAS2
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- Resveratrol
- Selisistat
- Cambinol
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SIRT2 |
sirtuin 2 |
- Initiation of Nuclear Envelope (NE) Reformation
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SMAD1 |
SMAD family member 1 |
- Signaling by BMP
- Ub-specific processing proteases
- RUNX2 regulates bone development
- Cardiogenesis
- Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
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SMAD2 |
SMAD family member 2 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Transcriptional regulation of pluripotent stem cells
- Ub-specific processing proteases
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- Germ layer formation at gastrulation
- Formation of axial mesoderm
- Formation of definitive endoderm
- Formation of definitive endoderm
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SMAD3 |
SMAD family member 3 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Ub-specific processing proteases
- RUNX3 regulates CDKN1A transcription
- RUNX3 regulates BCL2L11 (BIM) transcription
- Interleukin-37 signaling
- NOTCH4 Intracellular Domain Regulates Transcription
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- Germ layer formation at gastrulation
- Formation of axial mesoderm
- Formation of definitive endoderm
- Formation of definitive endoderm
- TGFBR3 expression
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SMAD4 |
SMAD family member 4 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Signaling by BMP
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Transcriptional regulation of pluripotent stem cells
- Ub-specific processing proteases
- RUNX2 regulates bone development
- RUNX3 regulates CDKN1A transcription
- RUNX3 regulates BCL2L11 (BIM) transcription
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- Cardiogenesis
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- Germ layer formation at gastrulation
- Formation of definitive endoderm
- Formation of definitive endoderm
- TGFBR3 expression
- Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
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- Colorectal cancer
- Juvenile polyposis syndrome
- Hereditary hemorrhagic telangiectasia (HHT)
- Pancreatic cancer
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SMAD5 |
SMAD family member 5 |
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SMAD7 |
SMAD family member 7 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- UCH proteinases
- Ub-specific processing proteases
- Interferon gamma signaling
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SNIP1 |
Smad nuclear interacting protein 1 |
- mRNA Splicing - Major Pathway
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SNW1 |
SNW domain containing 1 |
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- NOTCH1 Intracellular Domain Regulates Transcription
- NOTCH1 Intracellular Domain Regulates Transcription
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Notch-HLH transcription pathway
- mRNA Splicing - Major Pathway
- RUNX3 regulates NOTCH signaling
- RUNX3 regulates NOTCH signaling
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
- Formation of paraxial mesoderm
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SOX9 |
SRY-box transcription factor 9 |
- Deactivation of the beta-catenin transactivating complex
- Transcriptional regulation by RUNX2
- Transcriptional regulation of testis differentiation
- Transcriptional and post-translational regulation of MITF-M expression and activity
- Developmental Lineage of Pancreatic Acinar Cells
- Developmental Lineage of Pancreatic Ductal Cells
- Developmental Lineage of Multipotent Pancreatic Progenitor Cells
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- 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
- Campomelic dysplasia (CD)
- 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
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SP1 |
Sp1 transcription factor |
- PPARA activates gene expression
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Activation of gene expression by SREBF (SREBP)
- Oncogene Induced Senescence
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- Estrogen-dependent gene expression
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- Regulation of CDH11 gene transcription
- Regulation of CDH11 gene transcription
- Positive Regulation of CDH1 Gene Transcription
- NFE2L2 regulating tumorigenic genes
- TGFBR3 expression
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SP3 |
Sp3 transcription factor |
- SUMOylation of transcription factors
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SPHK1 |
sphingosine kinase 1 |
- Sphingolipid de novo biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- VEGFR2 mediated cell proliferation
- Extra-nuclear estrogen signaling
- PKR-mediated signaling
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SPIB |
Spi-B transcription factor |
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SREBF1 |
sterol regulatory element binding transcription factor 1 |
- Cholesterol biosynthesis
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
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- Doconexent
- Omega-3-acid ethyl esters
- Omega-3 fatty acids
- Fish oil
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SREBF2 |
sterol regulatory element binding transcription factor 2 |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Cholesterol biosynthesis
- PPARA activates gene expression
- Activation of gene expression by SREBF (SREBP)
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
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SRY |
sex determining region Y |
- Deactivation of the beta-catenin transactivating complex
- Transcriptional regulation of testis differentiation
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- 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
- 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
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