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SIX1 |
SIX homeobox 1 |
- Formation of the ureteric bud
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- Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
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SIX2 |
SIX homeobox 2 |
- Formation of the ureteric bud
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SIX3 |
SIX homeobox 3 |
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SIX6 |
SIX homeobox 6 |
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- Anophthalmia and microphthalmia (A/M)
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SKIL |
SKI like proto-oncogene |
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
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SKP2 |
S-phase kinase associated protein 2 |
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- SCF(Skp2)-mediated degradation of p27/p21
- Ub-specific processing proteases
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Regulation of RUNX2 expression and activity
- Neddylation
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Regulation of BACH1 activity
- Antigen processing: Ubiquitination & Proteasome degradation
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SMAD3 |
SMAD family member 3 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Ub-specific processing proteases
- RUNX3 regulates CDKN1A transcription
- RUNX3 regulates BCL2L11 (BIM) transcription
- Interleukin-37 signaling
- NOTCH4 Intracellular Domain Regulates Transcription
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- Germ layer formation at gastrulation
- Formation of axial mesoderm
- Formation of definitive endoderm
- Formation of definitive endoderm
- TGFBR3 expression
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SMAD4 |
SMAD family member 4 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Signaling by BMP
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Transcriptional regulation of pluripotent stem cells
- Ub-specific processing proteases
- RUNX2 regulates bone development
- RUNX3 regulates CDKN1A transcription
- RUNX3 regulates BCL2L11 (BIM) transcription
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- Cardiogenesis
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- Germ layer formation at gastrulation
- Formation of definitive endoderm
- Formation of definitive endoderm
- TGFBR3 expression
- Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
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- Colorectal cancer
- Juvenile polyposis syndrome
- Hereditary hemorrhagic telangiectasia (HHT)
- Pancreatic cancer
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SMARCB1 |
SWI/SNF related BAF chromatin remodeling complex subunit B1 |
- RMTs methylate histone arginines
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
- Formation of the canonical BAF (cBAF) complex
- Formation of the polybromo-BAF (pBAF) complex
- Formation of the embryonic stem cell BAF (esBAF) complex
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
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SMARCD1 |
SWI/SNF related BAF chromatin remodeling complex subunit D1 |
- RMTs methylate histone arginines
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
- Formation of the canonical BAF (cBAF) complex
- Formation of the polybromo-BAF (pBAF) complex
- Formation of the embryonic stem cell BAF (esBAF) complex
- Formation of the non-canonical BAF (ncBAF) complex
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
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SNCAIP |
synuclein alpha interacting protein |
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SNRPA |
small nuclear ribonucleoprotein polypeptide A |
- mRNA Splicing - Major Pathway
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SNRPC |
small nuclear ribonucleoprotein polypeptide C |
- mRNA Splicing - Major Pathway
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SOHLH1 |
spermatogenesis and oogenesis specific basic helix-loop-helix 1 |
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SPATA25 |
spermatogenesis associated 25 |
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SPG21 |
SPG21 abhydrolase domain containing, maspardin |
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- Hereditary spastic paraplegia (SPG)
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SPMIP9 |
sperm microtubule inner protein 9 |
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SRPK2 |
SRSF protein kinase 2 |
- Maturation of nucleoprotein
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- Adenine
- Purvalanol
- Phosphoaminophosphonic Acid-Adenylate Ester
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SSC4D |
scavenger receptor cysteine rich family member with 4 domains |
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STK16 |
serine/threonine kinase 16 |
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