HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols FHL2 and PKNOX2	Name 1 four and a half LIM domains 2	Name2 PBX/knotted 1 homeobox 2	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CCN3 and POLR2L	Name 1 cellular communication network factor 3	Name2 RNA polymerase II, I and III subunit L	Pathway 1	Pathway 2 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Drugs 1 Insulin human	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SNCA and CHMP4B	Name 1 synuclein alpha	Name2 charged multivesicular body protein 4B	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and STXBP3	Name 1 synuclein alpha	Name2 syntaxin binding protein 3	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Disinhibition of SNARE formation Translocation of SLC2A4 (GLUT4) to the plasma membrane	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and PCLO	Name 1 synuclein alpha	Name2 piccolo presynaptic cytomatrix protein	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Sensory processing of sound by inner hair cells of the cochlea	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and VPS13C	Name 1 synuclein alpha	Name2 vacuolar protein sorting 13 homolog C	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and CHMP2A	Name 1 synuclein alpha	Name2 charged multivesicular body protein 2A	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and CHMP2B	Name 1 synuclein alpha	Name2 charged multivesicular body protein 2B	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2 Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Novel Novel	Symbols SNCA and CHMP6	Name 1 synuclein alpha	Name2 charged multivesicular body protein 6	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and COLEC11	Name 1 synuclein alpha	Name2 collectin subfamily member 11	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Lectin pathway of complement activation Initial triggering of complement Scavenging by Class A Receptors	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and LRFN2	Name 1 synuclein alpha	Name2 leucine rich repeat and fibronectin type III domain containing 2	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Synaptic adhesion-like molecules	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and PHACTR1	Name 1 synuclein alpha	Name2 phosphatase and actin regulator 1	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and PSD3	Name 1 synuclein alpha	Name2 pleckstrin and Sec7 domain containing 3	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and SH3BP4	Name 1 synuclein alpha	Name2 SH3 domain binding protein 4	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Amino acids regulate mTORC1	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and VPS28	Name 1 synuclein alpha	Name2 VPS28 subunit of ESCRT-I	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and VPS37D	Name 1 synuclein alpha	Name2 VPS37D subunit of ESCRT-I	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols SNCA and VPS4A	Name 1 synuclein alpha	Name2 vacuolar protein sorting 4 homolog A	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel Novel	Symbols FOS and POLR2E	Name 1 Fos proto-oncogene, AP-1 transcription factor subunit	Name2 RNA polymerase II, I and III subunit E	Pathway 1 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling NPAS4 regulates expression of target genes Regulation of PD-L1(CD274) transcription	Pathway 2 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Drugs 1 Pseudoephedrine Nandrolone decanoate Nadroparin	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RELA and TAF4B	Name 1 RELA proto-oncogene, NF-kB subunit	Name2 TATA-box binding protein associated factor 4b	Pathway 1 Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses Regulation of NFE2L2 gene expression Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1 Glucosamine Dimethyl fumarate SC-236	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AKT2 and FSHR	Name 1 AKT serine/threonine kinase 2	Name2 follicle stimulating hormone receptor	Pathway 1 Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Regulation of MITF-M-dependent genes involved in pigmentation	Pathway 2 Hormone ligand-binding receptors G alpha (s) signalling events	Drugs 1 N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE	Drugs 2 Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin Corifollitropin alfa	Diseases 1 Ovarian cancer Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy	Diseases 2 Ovarian hyperstimulation syndrome (OHSS) Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
Novel	Symbols FHL2 and PKNOX2	Name 1 four and a half LIM domains 2	Name2 PBX/knotted 1 homeobox 2	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CCN3 and POLR2L	Name 1 cellular communication network factor 3	Name2 RNA polymerase II, I and III subunit L	Pathway 1	Pathway 2 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Drugs 1 Insulin human	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SNCA and CHMP4B	Name 1 synuclein alpha	Name2 charged multivesicular body protein 4B	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and STXBP3	Name 1 synuclein alpha	Name2 syntaxin binding protein 3	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Disinhibition of SNARE formation Translocation of SLC2A4 (GLUT4) to the plasma membrane	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and PCLO	Name 1 synuclein alpha	Name2 piccolo presynaptic cytomatrix protein	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Sensory processing of sound by inner hair cells of the cochlea	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and VPS13C	Name 1 synuclein alpha	Name2 vacuolar protein sorting 13 homolog C	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and CHMP2A	Name 1 synuclein alpha	Name2 charged multivesicular body protein 2A	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and CHMP2B	Name 1 synuclein alpha	Name2 charged multivesicular body protein 2B	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2 Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Novel	Symbols SNCA and CHMP6	Name 1 synuclein alpha	Name2 charged multivesicular body protein 6	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and COLEC11	Name 1 synuclein alpha	Name2 collectin subfamily member 11	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Lectin pathway of complement activation Initial triggering of complement Scavenging by Class A Receptors	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and LRFN2	Name 1 synuclein alpha	Name2 leucine rich repeat and fibronectin type III domain containing 2	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Synaptic adhesion-like molecules	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and PHACTR1	Name 1 synuclein alpha	Name2 phosphatase and actin regulator 1	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and PSD3	Name 1 synuclein alpha	Name2 pleckstrin and Sec7 domain containing 3	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and SH3BP4	Name 1 synuclein alpha	Name2 SH3 domain binding protein 4	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Amino acids regulate mTORC1	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and VPS28	Name 1 synuclein alpha	Name2 VPS28 subunit of ESCRT-I	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and VPS37D	Name 1 synuclein alpha	Name2 VPS37D subunit of ESCRT-I	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols SNCA and VPS4A	Name 1 synuclein alpha	Name2 vacuolar protein sorting 4 homolog A	Pathway 1 Amyloid fiber formation PKR-mediated signaling	Pathway 2 Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III	Drugs 1 Resveratrol Dequalinium Copper	Drugs 2	Diseases 1 Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)	Diseases 2
Novel	Symbols FOS and POLR2E	Name 1 Fos proto-oncogene, AP-1 transcription factor subunit	Name2 RNA polymerase II, I and III subunit E	Pathway 1 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling NPAS4 regulates expression of target genes Regulation of PD-L1(CD274) transcription	Pathway 2 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Drugs 1 Pseudoephedrine Nandrolone decanoate Nadroparin	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RELA and TAF4B	Name 1 RELA proto-oncogene, NF-kB subunit	Name2 TATA-box binding protein associated factor 4b	Pathway 1 Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses Regulation of NFE2L2 gene expression Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription	Pathway 2 HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Drugs 1 Glucosamine Dimethyl fumarate SC-236	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AKT2 and FSHR	Name 1 AKT serine/threonine kinase 2	Name2 follicle stimulating hormone receptor	Pathway 1 Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Regulation of MITF-M-dependent genes involved in pigmentation	Pathway 2 Hormone ligand-binding receptors G alpha (s) signalling events	Drugs 1 N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE	Drugs 2 Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin Corifollitropin alfa	Diseases 1 Ovarian cancer Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy	Diseases 2 Ovarian hyperstimulation syndrome (OHSS) Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis

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