SRPK2 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NPM2	nucleophosmin/nucleoplasmin 2	Replacement of protamines by nucleosomes in the male pronucleus
NSMCE4A	NSE4A component of SMC5/6 complex	SUMOylation of DNA damage response and repair proteins
NSRP1	nuclear speckle splicing regulatory protein 1	mRNA Splicing - Major Pathway
NSUN5P2	NSUN5 pseudogene 2
NTHL1	nth like DNA glycosylase 1	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding
NUP50	nucleoporin 50	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
NXF1	nuclear RNA export factor 1	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript
NXPE4	neurexophilin and PC-esterase domain family member 4
NXT2	nuclear transport factor 2 like export factor 2
OBI1	ORC ubiquitin ligase 1	Cyclin A/B1/B2 associated events during G2/M transition
OCEL1	occludin/ELL domain containing 1
OTOF	otoferlin	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea		Deafness, autosomal recessive
PABPC4	poly(A) binding protein cytoplasmic 4
PAK4	p21 (RAC1) activated kinase 4	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Fostamatinib
PALLD	palladin, cytoskeletal associated protein
PCBP1	poly(rC) binding protein 1	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
PCF11	PCF11 cleavage and polyadenylation factor subunit	RNA polymerase II transcribes snRNA genes mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
PDCL3	phosducin like 3
PDE7B	phosphodiesterase 7B	G alpha (s) signalling events	Caffeine Trapidil
PELI1	pellino E3 ubiquitin protein ligase 1	Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

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