PRKACA - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
STMN2	stathmin 2	RND1 GTPase cycle
STUB1	STIP1 homology and U-box containing protein 1	Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
SYN1	synapsin I	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Sensory processing of sound by inner hair cells of the cochlea	Adenosine 5'-[gamma-thio]triphosphate	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
SYN2	synapsin II	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
TH	tyrosine hydroxylase	Catecholamine biosynthesis	Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin	Primary torsion dystonia (PTD)
THOP1	thimet oligopeptidase 1	Antigen processing: Ubiquitination & Proteasome degradation
TNP1	transition protein 1
TNP2	transition protein 2
TPH1	tryptophan hydroxylase 1	Serotonin and melatonin biosynthesis NGF-stimulated transcription	Sapropterin LX1031 Telotristat ethyl
TPR	translocated promoter region, nuclear basket protein	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants		Thyroid cancer
TRIM55	tripartite motif containing 55
TRIM63	tripartite motif containing 63	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
TRIP10	thyroid hormone receptor interactor 10	Clathrin-mediated endocytosis RHOQ GTPase cycle
UBE3A	ubiquitin protein ligase E3A	Antigen processing: Ubiquitination & Proteasome degradation		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
UHRF1	ubiquitin like with PHD and ring finger domains 1	DNA methylation Chromatin modifications during the maternal to zygotic transition (MZT)
USP20	ubiquitin specific peptidase 20	Ub-specific processing proteases
VASP	vasodilator stimulated phosphoprotein	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
VIM	vimentin	Caspase-mediated cleavage of cytoskeletal proteins Striated Muscle Contraction Interleukin-4 and Interleukin-13 signaling RHOBTB1 GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Developmental Lineage of Mammary Gland Myoepithelial Cells	Artenimol Phenethyl Isothiocyanate
VTN	vitronectin	Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade Developmental Lineage of Pancreatic Ductal Cells	Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
WT1	WT1 transcription factor	Transcriptional regulation of testis differentiation Negative Regulation of CDH1 Gene Transcription Nephron development		Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD

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