GOLGA2 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
IFT27	intraflagellar transport 27	Intraflagellar transport Intraflagellar transport
IGFN1	immunoglobulin like and fibronectin type III domain containing 1
IHO1	interactor of HORMAD1 1
IKZF3	IKAROS family zinc finger 3
IL16	interleukin 16	Other interleukin signaling
INPP5J	inositol polyphosphate-5-phosphatase J	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
IQCE	IQ motif containing E	Activation of SMO
IQUB	IQ motif and ubiquitin domain containing
ISCU	iron-sulfur cluster assembly enzyme	Maturation of replicase proteins
ITGB5	integrin subunit beta 5	Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction
ITPKB	inositol-trisphosphate 3-kinase B	Synthesis of IP3 and IP4 in the cytosol
ITSN2	intersectin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle
KANK2	KN motif and ankyrin repeat domains 2
KANSL1	KAT8 regulatory NSL complex subunit 1	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
KAT5	lysine acetyltransferase 5	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Cardiogenesis	Coenzyme A S-Acetyl-Cysteine
KDM1A	lysine demethylase 1A	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production	Vafidemstat
KIAA1217	KIAA1217
KIFC3	kinesin family member C3
KRT1	keratin 1	Neutrophil degranulation Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Zinc Copper Zinc acetate	Ichthyosis hystrix, Curth-Macklin type Epidermolytic palmoplantar keratoderma (EPPK) Striate palmoplantar keratoderma Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
KRT18	keratin 18	Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells

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