FGF19

Name	fibroblast growth factor 19
Structure
Interactors	1 interactors: FGFR4
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Bacterium Negative Regulation Of Gene Expression Neurogenesis Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Response To Ethanol Positive Regulation Of D-glucose Import Positive Regulation Of JNK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Bile Acid Biosynthetic Process
Pathways	PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding FGFR4 ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs	Heparin
GWAS	Breast cancer ( 20453838 ) Craniofacial microsomia ( 26853712 ) Height ( 31217584 )
Entrez ID	9965
HPRD ID	04868
Ensembl ID	ENSG00000162344
Uniprot IDs	A0A7U3L4E7 O95750
PDB IDs	1PWA 2P23 6KTR 6NFJ
GO Terms Enriched among Interactors ?	Regulation Of Bile Acid Biosynthetic Process Regulation Of Bile Acid Metabolic Process Response To Bile Acid Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Regulation Of Extracellular Matrix Disassembly Phosphate Ion Homeostasis Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA Biosynthetic Process Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Extracellular Matrix Organization Sterol Homeostasis Regulation Of Steroid Biosynthetic Process Regulation Of DNA Biosynthetic Process Cholesterol Homeostasis Transport Vesicle Regulation Of Steroid Metabolic Process Protein Autophosphorylation Regulation Of Ketone Metabolic Process Protein Tyrosine Kinase Activity Positive Regulation Of Proteolysis Carbohydrate Homeostasis Receptor Complex Cell-cell Junction Glucose Homeostasis Heparin Binding Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Lipid Biosynthetic Process