FGD3

Name	FYVE, RhoGEF and PH domain containing 3
Structure
Interactors	1 interactors: CDC42
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle
GWAS	Longevity ( 33657282 ) Mean platelet volume ( 32888494 )
Entrez ID	89846
HPRD ID	10957
Ensembl ID	ENSG00000127084
Uniprot IDs	A8K9G1 Q5JSP0
PDB IDs	2COC
GO Terms Enriched among Interactors ?	Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Endothelin Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuropilin Signaling Pathway GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Golgi Localization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Cardiac Conduction System Development Embryonic Heart Tube Development Dendritic Spine Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Positive Regulation Of Lamellipodium Assembly Spindle Midzone Nuclear Migration Establishment Of Epithelial Cell Polarity Positive Regulation Of Filopodium Assembly Nucleus Localization Heart Process Dendritic Spine Organization Phagocytosis, Engulfment Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Macrophage Differentiation Neuron Projection Organization Substantia Nigra Development Regulation Of Filopodium Assembly Regulation Of Lamellipodium Assembly Cell Fate Determination Positive Regulation Of Substrate Adhesion-dependent Cell Spreading