CCK

Name	cholecystokinin
Structure
Interactors	7 interactors: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Neuron Migration Signal Transduction Axonogenesis Digestion Cholecystokinin Signaling Pathway Eating Behavior
Pathways	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs	Camostat
GWAS	Adult body size ( 32376654 ) Body mass index ( 24348519 28448500 28892062 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (SNP x SNP interaction) ( 22344221 ) Body size at age 10 ( 32376654 ) Night sleep phenotypes ( 27126917 )
Entrez ID	885
HPRD ID	00321
Ensembl ID	ENSG00000187094
Uniprot IDs	P06307 Q6FG82
PDB IDs	7EZH 7EZK 7EZM 7MBX 7MBY 7XOU 8IA7 9BKJ 9BKK
GO Terms Enriched among Interactors ?	Cholecystokinin Receptor Activity Metallopeptidase Activity Meprin A Complex Cholecystokinin Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Regulation Of Hormone Levels Proteolysis Protein Processing Hormone Metabolic Process Plasma Membrane Peptide Hormone Binding Protein Maturation Peptide Metabolic Process Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Glutamyl Aminopeptidase Activity Metalloendopeptidase Activity Neuropeptide Signaling Pathway Epidermal Growth Factor Receptor Ligand Maturation Negative Regulation Of G Protein-coupled Receptor Internalization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Localization To Secretory Granule Regulation Of Biological Quality Membrane Extracellular Space Negative Regulation Of Clathrin-dependent Endocytosis Hydrolase Activity Protein Metabolic Process 1-phosphatidylinositol-3-kinase Regulator Activity G Protein-coupled Receptor Signaling Pathway PH Reduction Gastric Acid Secretion Metallodipeptidase Activity Insulin Processing Cytoplasmic Vesicle Zinc Ion Binding Cardiac Left Ventricle Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Neurexin Family Protein Binding Glomerulus Development Negative Regulation Of Receptor Internalization Insulin Metabolic Process Peptide Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Neuropeptide Receptor Activity G Protein-coupled Receptor Activity