CDKL1

Name	cyclin dependent kinase like 1
Structure
Novel Interactors	1 novel interactors: IRS2
Interactors	2 interactors: SMURF1 TGFBR1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ciliary Transition Zone Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Heart Development Regulation Of Cell Cycle Regulation Of Cilium Assembly
Drugs	Fostamatinib
GWAS	Aspartate aminotransferase levels ( 33547301 ) Cognitive performance ( 20125193 ) Lead levels ( 26025379 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) Systolic blood pressure ( 30578418 )
Entrez ID	8814
HPRD ID	10348
Ensembl ID	ENSG00000100490
Uniprot IDs	A0A5H1ZRP5 A0A9S7JKS7 Q00532
PDB IDs	4AGU
GO Terms Enriched among Interactors ?	I-SMAD Binding SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Epithelial Cell Proliferation Regulation Of Developmental Growth Ventricular Compact Myocardium Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Proepicardium Development Positive Regulation Of Growth Ameboidal-type Cell Migration Gland Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Coronary Vascular Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cell Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Germ Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Projection Organization Vascular Endothelial Cell Proliferation Transforming Growth Factor Beta Receptor Activity Epicardium Morphogenesis Trophoblast Cell Migration Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Activity, Type I Transforming Growth Factor Beta Ligand-receptor Complex Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Activin Receptor Binding Substrate Localization To Autophagosome Engulfment Of Target By Autophagosome Coronary Artery Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cell Surface Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Cell Growth Type II Transforming Growth Factor Beta Receptor Binding