TTYH3

Name	tweety family member 3
Structure
Novel Interactors	1 novel interactors: MAD1L1
Interactors	4 interactors: ITCH MAPK3 NEDD4 YAP1
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Extracellular Exosome
	Molecular Function	Volume-sensitive Anion Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Calcium Ion Binding Protein Binding Metal Ion Binding Volume-sensitive Chloride Channel Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways	Stimuli-sensing channels
GWAS	Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725 ) Daytime sleep phenotypes ( 27126917 ) Platelet distribution width ( 32888494 ) Ulcerative colitis ( 23128233 )
Entrez ID	80727
HPRD ID	12333
Ensembl ID	ENSG00000136295
Uniprot IDs	Q9C0H2
PDB IDs	7P5C
GO Terms Enriched among Interactors ?	Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of T Cell Activation Proline-rich Region Binding Intracellular Signal Transduction Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Regulation Of Leukocyte Proliferation Regulation Of Cellular Component Organization Negative Regulation Of Cell Adhesion Thymus Development Regulation Of Protein Catabolic Process Protein Monoubiquitination Mesenchyme Development Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Cytokine-mediated Signaling Pathway Receptor Internalization Regulation Of Signal Transduction Endocytosis Protein K63-linked Ubiquitination Negative Regulation Of T Cell Proliferation Regulation Of Stem Cell Differentiation Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation MAD1 Complex Enterocyte Differentiation Regulation Of Cell Communication Positive Regulation Of Catabolic Process Regulation Of Signaling Hematopoietic Or Lymphoid Organ Development Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Chromosome Organization Regulation Of Cell Population Proliferation Import Into Cell Regulation Of Cell Activation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Channel Inhibitor Activity Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Catabolic Process