TUSC3

Name	tumor suppressor candidate 3
Structure
Interactors	2 interactors: BMI1 PPP1CA
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Oligosaccharyltransferase Complex Membrane
	Molecular Function	Magnesium Ion Transmembrane Transporter Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Magnesium Ion Transport Protein N-linked Glycosylation Via Asparagine Cognition Transmembrane Transport Magnesium Ion Transmembrane Transport
Pathways	Asparagine N-linked glycosylation Miscellaneous transport and binding events Maturation of spike protein PD-L1(CD274) glycosylation and translocation to plasma membrane
Diseases	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS	Adult body size ( 32376654 ) Body size at age 10 ( 32376654 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Intelligence ( 22449649 ) Metabolite levels ( 23823483 ) Methamphetamine dependence ( 23594818 ) Prudent dietary pattern ( 28644415 ) Pulmonary function decline ( 22424883 ) Response to cytadine analogues (cytosine arabinoside) ( 24483146 ) Response to SSRI in MDD or openness ( 29559929 )
Entrez ID	7991
HPRD ID	03228
Ensembl ID	ENSG00000104723
Uniprot IDs	D6RA37 D6RIY7 Q13454
PDB IDs	4M8G 4M90 4M91 4M92
GO Terms Enriched among Interactors ?	RING-like Zinc Finger Domain Binding Regulation Of Adaxial/abaxial Pattern Formation Regulation Of Apoptotic Signaling Pathway Rostrocaudal Neural Tube Patterning Cell Division Positive Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Ubiquitin-protein Transferase Activator Activity Double-strand Break Repair Via Alternative Nonhomologous End Joining Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Somatic Stem Cell Division Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Ubiquitin-protein Transferase Activity Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Segment Specification PRC1 Complex Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion Positive Regulation Of Glycogen Biosynthetic Process Response To Lead Ion Entrainment Of Circadian Clock By Photoperiod Regulation Of Translation In Response To Stress Negative Regulation Of Transcription Elongation By RNA Polymerase II Stem Cell Division Regulation Of Ubiquitin-protein Transferase Activity Protein Phosphatase 1 Binding Negative Regulation Of DNA-templated Transcription, Elongation PcG Protein Complex Photoperiodism Entrainment Of Circadian Clock Cellular Response To Dexamethasone Stimulus Regulation Of Glycogen Biosynthetic Process Regulation Of Kidney Development DNA Methylation-dependent Constitutive Heterochromatin Formation Positive Regulation Of Protein-containing Complex Disassembly Ribonucleoprotein Complex Binding Regulation Of Glycogen Metabolic Process Response To Dexamethasone Positive Regulation Of B Cell Proliferation Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand