RPP21

Name	ribonuclease P subunit p21
Structure
Novel Interactors	1 novel interactors: TRAF6
Interactors	3 interactors: RPP30 RPP38 RPP40
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Multimeric Ribonuclease P Complex Endoribonuclease Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding Metal Ion Binding
	Biological Process	TRNA 5'-leader Removal RNA Processing TRNA Processing Response To Xenobiotic Stimulus
Pathways	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
GWAS	Anxiety ( 33859377 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cutaneous lupus erythematosus ( 25827949 ) Lung cancer ( 31577861 ) Moderate to vigorous physical activity levels ( 29899525 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Type 1 diabetes (age at diagnosis) ( 33179336 )
Entrez ID	79897
HPRD ID	15275
Ensembl ID	ENSG00000241370
Uniprot IDs	A0A1U9X8H3 Q9H633
PDB IDs	6AHR 6AHU
GO Terms Enriched among Interactors ?	Nucleolar Ribonuclease P Complex Ribonuclease MRP Complex Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing TRNA Processing TRNA Metabolic Process RRNA Processing RRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Ribonuclease MRP Activity Nucleobase-containing Compound Metabolic Process RNA Processing Nucleolus Ribonuclease P Complex Interleukin-17A-mediated Signaling Pathway CD40 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Protein Kinase B Binding Interleukin-33-mediated Signaling Pathway T-helper 1 Type Immune Response Interleukin-17-mediated Signaling Pathway RNA Binding Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Positive Regulation Of JUN Kinase Activity Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Bone Remodeling Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Myeloid Dendritic Cell Differentiation Stimulatory C-type Lectin Receptor Signaling Pathway Protein Branched Polyubiquitination Cellular Response To Lectin Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Bone Resorption Positive Regulation Of T Cell Cytokine Production Regulation Of Receptor Localization To Synapse Interleukin-1-mediated Signaling Pathway Positive Regulation Of Osteoclast Differentiation Regulation Of Protein Localization To Synapse Endolysosomal Toll-like Receptor Signaling Pathway