RPAP3

Name	RNA polymerase II associated protein 3
Structure
Interactors	11 interactors: APP DAPK1 FBXO25 HSP90AA1 HSPB1 ITCH LRRK2 MFHAS1 NEDD4 TERF1 TGFBR1
GO Annotations	Cellular Component	Cytosol Cilium Ciliary Basal Body R2TP Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	Protein Binding
	Biological Process	Protein Stabilization
GWAS	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Cognitive performance (processing speed) ( 31598132 ) Optic nerve measurement (cup-to-disc ratio) ( 28061514 ) Rosacea symptom severity ( 29771307 ) Vertical cup-disc ratio ( 25241763 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Entrez ID	79657
HPRD ID	07970
Ensembl ID	ENSG00000005175
Uniprot IDs	Q9H6T3
PDB IDs	4CGV 4CGW 6EZ4 6FD7 6FDP 6FDT 6FM8 6FO1 6GXZ 6ZBK
GO Terms Enriched among Interactors ?	Positive Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Catabolic Process Response To Stress Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Cellular Response To Manganese Ion Positive Regulation Of Metabolic Process Response To Other Organism Regulation Of Protein Modification Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Response To Manganese Ion Positive Regulation Of Tumor Necrosis Factor Production Protein Homodimerization Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Golgi-associated Vesicle Response To External Biotic Stimulus Cellular Response To Catecholamine Stimulus Regulation Of Intracellular Signal Transduction GTP Binding Regulation Of Autophagy Syntaxin-1 Binding Protein Metabolic Process Response To Catecholamine Regulation Of Apoptotic Signaling Pathway Transmembrane Transporter Binding Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Telomere Maintenance Via Telomerase Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of JNK Cascade Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Nucleus Negative Regulation Of Apoptotic Process RNA-templated DNA Biosynthetic Process Regulation Of Innate Immune Response Endocytosis Apoptotic Process Protein Refolding