DENND2B

Name	DENN domain containing 2B
Structure	No pdb structure
Novel Interactors	1 novel interactors: TCF4
Interactors	2 interactors: ABL1 SMAD2
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Cell Cortex Membrane Recycling Endosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Positive Regulation Of ERK1 And ERK2 Cascade
Pathways	RAB GEFs exchange GTP for GDP on RABs
GWAS	No GWAS studies recorded
Entrez ID	6764
HPRD ID	00780
Ensembl ID	ENSG00000166444
Uniprot IDs	P78524
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Neuroepithelial Cell Differentiation Post-embryonic Development Response To Transforming Growth Factor Beta Transitional One Stage B Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Nicotinate-nucleotide Adenylyltransferase Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Podocyte Apoptotic Process DN4 Thymocyte Differentiation Protein Localization To Microtubule Plus-end Protein Localization To Cytoplasmic Microtubule Plus-end Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of BMP Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Homomeric SMAD Protein Complex Paraxial Mesoderm Morphogenesis Beta-catenin-TCF7L2 Complex Microspike Assembly Regulation Of Cell Differentiation B-1 B Cell Homeostasis Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Cerebellum Morphogenesis Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress B Cell Proliferation Involved In Immune Response Neuropilin Signaling Pathway Transcription Regulator Complex Mesoderm Morphogenesis TFIIB-class Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Establishment Of T Cell Polarity Response To Growth Factor Supercoiled DNA Binding Positive Regulation Of Blood Vessel Branching Pericardium Development Mitochondrial Depolarization Cellular Response To Dopamine Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Odontoblast Differentiation SMAD Protein Complex Trophoblast Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Blood Vessel Branching Response To Dopamine