P2RY12

Name	purinergic receptor P2Y12
Structure
Interactors	1 interactors: GNAI2
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Cell Projection Membrane Cell Body Membrane
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled ADP Receptor Activity G Protein-coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Monoatomic Ion Transport Substrate-dependent Cell Migration, Cell Extension Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Calcium-mediated Signaling Cerebral Cortex Radial Glia-guided Migration Cell Projection Organization Lamellipodium Assembly Platelet Activation Positive Regulation Of Integrin Activation By Cell Surface Receptor Linked Signal Transduction Positive Regulation Of Cell Adhesion Mediated By Integrin G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Monoatomic Ion Transport Response To Axon Injury Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Aggregation Cellular Response To ATP Visual System Development Positive Regulation Of Ruffle Assembly Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Migration
Pathways	ADP signalling through P2Y purinoceptor 12 P2Y receptors G alpha (i) signalling events
Drugs	Ticlopidine Treprostinil Clopidogrel Promethazine Epoprostenol Regrelor Prasugrel Elinogrel Cangrelor Ticagrelor Selatogrel Vicagrel
GWAS	Diverticular disease ( 30177863 )
Entrez ID	64805
HPRD ID	02743
Ensembl ID	ENSG00000169313
Uniprot IDs	A8K7T1 Q9H244
PDB IDs	4NTJ 4PXZ 4PY0 7PP1 7XXI
GO Terms Enriched among Interactors ?	Purinergic Nucleotide Receptor Signaling Pathway Guanyl Nucleotide Binding Regulation Of Urine Volume Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Regulation Of Superoxide Metabolic Process Heterotrimeric G-protein Complex Negative Regulation Of Exocytosis Negative Regulation Of Synaptic Transmission Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Acetylcholine Receptor Signaling Pathway Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Signal Transduction Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process G Protein-coupled Receptor Binding Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Cell Body Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Extracellular Vesicle Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Renal System Process Regulation Of Regulated Secretory Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Nutrient Negative Regulation Of Catalytic Activity Negative Regulation Of Secretion Regulation Of Exocytosis Midbody Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Calcium Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway