PRL

Name	prolactin
Structure
Novel Interactors	1 novel interactors: SCARB1
Interactors	6 interactors: MEOX2 PPIB PRLR S100A6 S100P UBQLN4
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lumen Vesicle
	Molecular Function	Prolactin Receptor Binding Hormone Activity Protein Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Negative Regulation Of Angiogenesis Mammary Gland Development Response To Nutrient Levels Prolactin Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MiRNA Transcription Positive Regulation Of Lactation
Pathways	Prolactin receptor signaling Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling Developmental Lineage of Mammary Gland Alveolar Cells
GWAS	Alanine aminotransferase levels ( 33547301 ) Aspartate aminotransferase levels ( 33547301 ) Chronic obstructive pulmonary disease ( 30804561 ) Obesity ( 19151714 ) Paget's disease ( 21623375 ) Pulmonary function (smoking interaction) ( 23284291 ) Refractive error ( 32231278 )
Entrez ID	5617
HPRD ID	07180
Ensembl ID	ENSG00000172179
Uniprot IDs	P01236 Q5I0G2 Q5THQ0
PDB IDs	1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ
GO Terms Enriched among Interactors ?	Positive Regulation Of Sphingolipid Mediated Signaling Pathway Endothelial Cell Migration Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity High Density Lipoprotein Particle Mediated Signaling Lipopolysaccharide Transport Prolactin Receptor Activity Calcium-dependent Protein Binding Nuclear Proteasome Complex Positive Regulation Of Nitric Oxide Mediated Signal Transduction Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Regulation Of Phosphatidylcholine Catabolic Process Somite Specification Perinuclear Region Of Cytoplasm Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Autophagosome Maturation Cytosolic Proteasome Complex