RNF43

Name	ring finger protein 43
Structure
Novel Interactors	1 novel interactors: MKS1
Interactors	9 interactors: EPOR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N ZNRF3
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Stem Cell Proliferation
Pathways	Regulation of FZD by ubiquitination Signaling by RNF43 mutants
GWAS	Circulating myeloperoxidase levels (plasma) ( 23620142 ) Cognitive function ( 25644384 ) Hemoglobin levels ( 32327693 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Pancreatic cancer ( 20686608 ) Prostate cancer ( 29892016 ) Refractive error ( 32231278 ) Vitamin D levels ( 25208829 )
Entrez ID	54894
HPRD ID	07896
Ensembl ID	ENSG00000108375
Uniprot IDs	J3KSE3 Q68DV7
PDB IDs	4KNG 8WVU
GO Terms Enriched among Interactors ?	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Protein Modification Process Transferase Activity Catabolic Process Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Nucleotide Binding Protein K63-linked Ubiquitination Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Regulation Of Non-canonical Wnt Signaling Pathway Protein K6-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process Erythropoietin Receptor Activity Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination TOR Signaling Wnt Receptor Catabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex UBC13-MMS2 Complex Regulation Of BMP Signaling Pathway Nucleoplasm Negative Regulation Of Cellular Response To Growth Factor Stimulus ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Post-translational Protein Modification