SASH3

Name	SAM and SH3 domain containing 3
Structure	No pdb structure
Interactors	5 interactors: APP BMPR1B SMAD4 SMAD7 SMURF1
GO Annotations	Cellular Component	Nucleus Cytoplasm
	Biological Process	B Cell Homeostasis Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Adaptive Immune Response Positive Regulation Of B Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Lymphocyte Activation Regulation Of Intracellular Signal Transduction
GWAS	No GWAS studies recorded
Entrez ID	54440
HPRD ID	02342
Ensembl ID	ENSG00000122122
Uniprot IDs	O75995
PDB IDs	Not available
GO Terms Enriched among Interactors ?	I-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Response To Growth Factor Negative Regulation Of Chondrocyte Proliferation BMP Signaling Pathway Activin Receptor Binding Heteromeric SMAD Protein Complex Positive Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Proteolysis Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Activin Receptor Signaling Pathway R-SMAD Binding Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ventricular Septum Morphogenesis Regulation Of Developmental Process Regulation Of Developmental Growth Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Chondrocyte Differentiation Developmental Growth Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cardiac Muscle Tissue Morphogenesis Regulation Of Cell Growth Cellular Developmental Process Collagen Binding Regulation Of Multicellular Organismal Process Negative Regulation Of BMP Signaling Pathway Regulation Of SMAD Protein Signal Transduction Regulation Of Signal Transduction Regulation Of Cartilage Development Cardiac Septum Morphogenesis Muscle Tissue Morphogenesis Regulation Of MiRNA Transcription