PIK3C2A

Name	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Structure
Interactors	3 interactors: AMOT EGFR ERBB2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity Clathrin Binding 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Exocytosis Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Vascular Associated Smooth Muscle Contraction Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Clathrin Coat Assembly Membrane Organization Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
GWAS	Body mass index ( 26426971 ) Platelet count ( 32888494 ) Schizophrenia or bipolar disorder ( 24280982 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 )
Entrez ID	5286
HPRD ID	04672
Ensembl ID	ENSG00000011405
Uniprot IDs	B4DG55 L7RRS0 O00443
PDB IDs	2AR5 2IWL 2REA 2RED 6BTY 6BTZ 6BU0 6BUB
GO Terms Enriched among Interactors ?	ERBB2-EGFR Signaling Pathway ERBB2 Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Basal Plasma Membrane Endocytic Vesicle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ruffle Membrane Negative Regulation Of Developmental Process Protein Tyrosine Kinase Activity Multivesicular Body, Internal Vesicle Lumen Positive Regulation Of Cell Growth Shc-EGFR Complex Negative Regulation Of Multicellular Organismal Process ERBB3:ERBB2 Complex Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Transmembrane Signaling Receptor Activity Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Positive Regulation Of Protein Phosphorylation RNA Polymerase I Core Binding Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase C Signaling Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Growth Epidermal Growth Factor Binding Endosome Membrane Basolateral Plasma Membrane Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Angiostatin Binding Tube Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Angiogenesis Negative Regulation Of Immature T Cell Proliferation Intracellular Signal Transduction Regulation Of Vasculature Development Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Neuron Differentiation Regulation Of Epithelial Cell Proliferation