NDUFS4

Name	NADH:ubiquinone oxidoreductase subunit S4
Structure
Interactors	2 interactors: APP UBE2G2
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Regulation Of Protein Phosphorylation Mitochondrial Electron Transport, NADH To Ubiquinone Brain Development Aerobic Respiration Electron Transport Chain Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Response To CAMP Reactive Oxygen Species Metabolic Process Proton Transmembrane Transport
Pathways	Respiratory electron transport Complex I biogenesis
Drugs	NADH
Diseases	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS	Acne (severe) ( 24927181 ) Blond vs. brown/black hair color ( 30531825 ) Midgestational circulating levels of PCBs ( 28235828 ) Mitochondrial heteroplasmy measurement ( 33731350 ) Monobrow ( 27182965 ) Night sleep phenotypes ( 27126917 ) Schizophrenia ( 34099189 ) Schizophrenia x sex interaction ( 34099189 ) Verbal memory ( 29907492 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 )
Entrez ID	4724
HPRD ID	04073
Ensembl ID	ENSG00000164258
Uniprot IDs	A0A0S2Z433 O43181
PDB IDs	5XTB 5XTD 5XTH 5XTI
GO Terms Enriched among Interactors ?	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Protein Transport Axon Choice Point Recognition Regulation Of Establishment Of Protein Localization Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Response To Peptide Response To Cytokine Cellular Response To Manganese Ion Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Exit From Endoplasmic Reticulum Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding