LMAN1

Name	lectin, mannose binding 1
Structure
Interactors	6 interactors: APP CEBPA F8 LINC00632 MCFD2 OGT
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Sarcomere COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	In Utero Embryonic Development Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Blood Coagulation Gene Expression Positive Regulation Of Organelle Organization Protein Transport Vesicle-mediated Transport Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport Negative Regulation Of Protein Targeting To Mitochondrion
Pathways	COPII-mediated vesicle transport Cargo concentration in the ER RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Transport to the Golgi and subsequent modification
Drugs	Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases	Combined deficiency of factors V and VIII (F5F8D)
GWAS	Cardiac troponin-I levels ( 31014085 ) Chronotype ( 27494321 ) Morning vs. evening chronotype ( 27494321 )
Entrez ID	3998
HPRD ID	03338
Ensembl ID	ENSG00000074695
Uniprot IDs	P49257
PDB IDs	3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE 8JP4 8JP5 8JP6 8JP7 8JP8 8JP9 8JPG
GO Terms Enriched among Interactors ?	Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Platelet Alpha Granule Lumen Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Acute-phase Response RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Acute Inflammatory Response Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Chromatin DNA Binding Golgi Lumen Defense Response Acetylcholine Receptor Activator Activity Lipoprotein Particle Notch Signaling Pathway Positive Regulation Of Protein Import Inflammatory Response Response To Vitamin B2 C/EBP Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Memory Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Protein O-acetylglucosaminyltransferase Activity Response To Nutrient Regulation Of Synapse Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Axon Midline Choice Point Recognition