THEMIS

Name	thymocyte selection associated
Structure	No pdb structure
Interactors	1 interactors: PRMT6
GO Annotations	Cellular Component	Nucleus Cytoplasm Cell-cell Junction COP9 Signalosome
	Molecular Function	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive T Cell Selection Negative T Cell Selection T Cell Receptor Signaling Pathway
GWAS	Asthma ( 31619474 31959851 34103634 ) Celiac disease ( 20190752 25920553 ) Crohn's disease ( 28067908 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Hepcidin/ferritin ratio ( 27846281 ) Multiple sclerosis ( 21833088 31604244 ) Nicotine dependence and major depression (severity of comorbidity) ( 30287806 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Recalcitrant atopic dermatitis ( 25935106 )
Entrez ID	387357
HPRD ID	16662
Ensembl ID	ENSG00000172673
Uniprot IDs	Q8N1K5
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Base-excision Repair Regulation Of Megakaryocyte Differentiation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Senescence Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Mitochondrion Organization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteolysis Histone Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Methyltransferase Activity