HPGD

Name	15-hydroxyprostaglandin dehydrogenase
Structure
Novel Interactors	1 novel interactors: PRDM1
Interactors	1 interactors: APP
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol Basolateral Plasma Membrane Extracellular Exosome
	Molecular Function	Prostaglandin E Receptor Activity 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding NAD Binding NAD+ Binding
	Biological Process	Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Prostaglandin Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Female Pregnancy Parturition Lipoxygenase Pathway Ovulation Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Response To Ethanol Negative Regulation Of Cell Cycle Thrombin-activated Receptor Signaling Pathway Ductus Arteriosus Closure Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Prostaglandin Catabolic Process
Pathways	Biosynthesis of Lipoxins (LX) Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Biosynthesis of D-series resolvins Biosynthesis of E-series 18(S)-resolvins
Drugs	NADH
Diseases	Primary hypertrophic osteoarthropathy (PHO)
GWAS	Alcohol dependence ( 26365420 ) Metabolite levels ( 23823483 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Entrez ID	3248
HPRD ID	03406
Ensembl ID	ENSG00000164120
Uniprot IDs	E9PBZ2 P15428
PDB IDs	2GDZ 8CVN 8CWL 8FD8
GO Terms Enriched among Interactors ?	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Sebum Secreting Cell Proliferation Regulation Of Extrathymic T Cell Differentiation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of NK T Cell Differentiation Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Retinal Bipolar Neuron Differentiation Innate Immune Response Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion