NXPH1

Name	neurexophilin 1
Structure	No pdb structure
Novel Interactors	1 novel interactors: MAD1L1
Interactors	1 interactors: NRXN1
GO Annotations	Cellular Component	Extracellular Region Synaptic Cleft Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Signaling Receptor Binding
	Biological Process	Modulation Of Chemical Synaptic Transmission
GWAS	Angiotensin-converting enzyme inhibitor intolerance ( 28030426 ) Brain imaging ( 20100581 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Metabolite levels ( 23823483 ) Neuroticism ( 18762592 ) Obesity-related traits ( 23251661 ) Protein quantitative trait loci ( 18464913 ) Response to fenofibrate ( 22890011 ) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101 ) Waist-to-hip ratio adjusted for body mass index ( 27195708 ) Working memory ( 31598132 )
Entrez ID	30010
HPRD ID	06867
Ensembl ID	ENSG00000122584
Uniprot IDs	P58417 Q3LID8
PDB IDs	Not available
GO Terms Enriched among Interactors ?	MAD1 Complex Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Deactivation Of Mitotic Spindle Assembly Checkpoint Kinetochore Binding Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Filopodium Assembly Cerebellar Granule Cell Differentiation Postsynaptic Density Protein 95 Clustering Neuronal Signal Transduction NMDA Selective Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Positive Regulation Of Neuromuscular Synaptic Transmission Trans-synaptic Protein Complex Gephyrin Clustering Involved In Postsynaptic Density Assembly AMPA Selective Glutamate Receptor Signaling Pathway Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuroligin Family Protein Binding Type 1 Fibroblast Growth Factor Receptor Binding Postsynaptic Membrane Assembly Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Sister Chromatid Segregation Vocal Learning Postsynaptic Membrane Organization Positive Regulation Of Synapse Maturation Presynaptic Membrane Assembly Observational Learning Presynaptic Membrane Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Synaptic Vesicle Clustering Nuclear Pore Nuclear Basket Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Regulation Of Metaphase Plate Congression Auditory Behavior Negative Regulation Of Cellular Component Organization Neuron Cell-cell Adhesion Glutamatergic Neuron Differentiation Mechanosensory Behavior Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore